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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CASP4
All Species:
6.97
Human Site:
S274
Identified Species:
19.17
UniProt:
P49662
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49662
NP_001216.1
377
43262
S274
W
V
R
D
S
P
A
S
L
E
V
A
S
S
Q
Chimpanzee
Pan troglodytes
XP_508729
377
43239
S274
W
V
R
D
S
P
A
S
L
E
V
A
S
S
Q
Rhesus Macaque
Macaca mulatta
Q153Z0
421
47740
S318
T
T
D
S
G
K
A
S
A
D
T
H
G
Q
L
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P70343
373
42737
P270
W
I
R
E
S
S
K
P
Q
L
C
R
G
V
D
Rat
Rattus norvegicus
Q920D5
420
47818
T317
S
T
S
K
G
I
A
T
A
D
T
D
E
E
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509500
456
52101
G353
A
W
V
S
D
S
L
G
P
S
A
T
S
S
Q
Chicken
Gallus gallus
Q98943
424
47941
S309
Q
R
D
G
K
E
R
S
D
S
P
G
C
E
E
Frog
Xenopus laevis
P55865
386
43644
G281
C
R
G
E
N
K
G
G
L
L
V
R
D
D
V
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P42573
503
56598
G389
R
G
W
D
N
R
D
G
P
L
F
N
F
L
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
49.4
N.A.
N.A.
59.4
48
N.A.
42.3
24
40.9
N.A.
N.A.
N.A.
N.A.
25
N.A.
Protein Similarity:
100
99.7
65.3
N.A.
N.A.
72.4
62.1
N.A.
57.6
44.3
58.8
N.A.
N.A.
N.A.
N.A.
41.7
N.A.
P-Site Identity:
100
100
13.3
N.A.
N.A.
20
6.6
N.A.
20
6.6
13.3
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
100
20
N.A.
N.A.
33.3
20
N.A.
20
13.3
26.6
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
0
0
0
0
45
0
23
0
12
23
0
0
0
% A
% Cys:
12
0
0
0
0
0
0
0
0
0
12
0
12
0
12
% C
% Asp:
0
0
23
34
12
0
12
0
12
23
0
12
12
12
12
% D
% Glu:
0
0
0
23
0
12
0
0
0
23
0
0
12
23
12
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
0
% F
% Gly:
0
12
12
12
23
0
12
34
0
0
0
12
23
0
12
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
12
0
0
0
% H
% Ile:
0
12
0
0
0
12
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
12
12
23
12
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
12
0
34
34
0
0
0
12
12
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
23
0
0
0
0
0
0
12
0
0
0
% N
% Pro:
0
0
0
0
0
23
0
12
23
0
12
0
0
0
0
% P
% Gln:
12
0
0
0
0
0
0
0
12
0
0
0
0
12
34
% Q
% Arg:
12
23
34
0
0
12
12
0
0
0
0
23
0
0
0
% R
% Ser:
12
0
12
23
34
23
0
45
0
23
0
0
34
34
0
% S
% Thr:
12
23
0
0
0
0
0
12
0
0
23
12
0
0
0
% T
% Val:
0
23
12
0
0
0
0
0
0
0
34
0
0
12
12
% V
% Trp:
34
12
12
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _