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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MCM2
All Species:
36.36
Human Site:
S541
Identified Species:
53.33
UniProt:
P49736
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49736
NP_004517.2
904
101896
S541
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Chimpanzee
Pan troglodytes
XP_001136482
895
100908
S532
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Rhesus Macaque
Macaca mulatta
XP_001099580
870
97929
I517
K
H
K
V
R
G
D
I
N
V
L
L
C
G
D
Dog
Lupus familis
XP_541736
1001
113024
S639
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Cat
Felis silvestris
Mouse
Mus musculus
P97310
904
102059
S541
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Rat
Rattus norvegicus
NP_001101343
905
102125
S542
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518428
911
102482
S548
K
Y
V
E
K
V
S
S
R
A
I
F
T
T
G
Chicken
Gallus gallus
NP_001006139
888
100332
S528
K
Y
I
E
K
V
S
S
R
A
I
F
T
T
G
Frog
Xenopus laevis
P55861
886
100243
S526
K
Y
V
E
K
V
A
S
R
A
V
F
T
T
G
Zebra Danio
Brachydanio rerio
NP_775364
880
98286
S520
K
Y
V
E
K
V
A
S
R
A
V
F
T
T
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49735
887
100396
P526
K
Y
T
E
K
V
A
P
R
A
V
F
T
T
G
Honey Bee
Apis mellifera
XP_395109
1005
114136
P645
K
Y
V
E
K
I
A
P
R
S
V
F
T
T
G
Nematode Worm
Caenorhab. elegans
Q21902
759
84917
A436
E
G
G
A
M
V
L
A
D
G
G
V
V
C
I
Sea Urchin
Strong. purpuratus
XP_001177558
884
100012
P526
K
Y
V
E
K
T
A
P
R
A
V
F
T
T
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Q43704
768
85163
A445
N
A
R
C
S
V
I
A
A
A
N
P
I
Y
G
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P29469
868
98761
I537
K
H
S
I
R
G
D
I
N
V
L
L
L
G
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
95.8
87.4
N.A.
95.5
96
N.A.
93.1
88.2
86.7
80.1
N.A.
63.9
58.4
26.7
73.4
Protein Similarity:
100
99
96.1
89.1
N.A.
97.7
98.3
N.A.
95.7
93.8
93
87.6
N.A.
79.3
73.5
43.2
86.5
P-Site Identity:
100
100
6.6
100
N.A.
100
100
N.A.
93.3
100
80
80
N.A.
73.3
60
6.6
66.6
P-Site Similarity:
100
100
26.6
100
N.A.
100
100
N.A.
100
100
100
100
N.A.
86.6
93.3
20
86.6
Percent
Protein Identity:
N.A.
30.3
N.A.
N.A.
41.9
N.A.
Protein Similarity:
N.A.
48.8
N.A.
N.A.
58.9
N.A.
P-Site Identity:
N.A.
20
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
0
32
13
7
75
0
0
0
0
0
% A
% Cys:
0
0
0
7
0
0
0
0
0
0
0
0
7
7
0
% C
% Asp:
0
0
0
0
0
0
13
0
7
0
0
0
0
0
13
% D
% Glu:
7
0
0
75
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
75
0
0
0
% F
% Gly:
0
7
7
0
0
13
0
0
0
7
7
0
0
13
82
% G
% His:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
38
7
0
7
7
13
0
0
44
0
7
0
7
% I
% Lys:
88
0
7
0
75
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
7
0
0
0
13
13
7
0
0
% L
% Met:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
0
0
0
13
0
7
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
19
0
0
0
7
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
7
0
13
0
0
0
75
0
0
0
0
0
0
% R
% Ser:
0
0
7
0
7
0
44
57
0
7
0
0
0
0
0
% S
% Thr:
0
0
7
0
0
7
0
0
0
0
0
0
75
75
0
% T
% Val:
0
0
32
7
0
75
0
0
0
13
32
7
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
75
0
0
0
0
0
0
0
0
0
0
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _