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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACOT2
All Species:
28.48
Human Site:
Y269
Identified Species:
62.67
UniProt:
P49753
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49753
NP_006812.3
483
53218
Y269
M
E
T
L
H
L
E
Y
F
E
E
A
M
N
Y
Chimpanzee
Pan troglodytes
XP_510048
483
53239
Y269
M
E
T
L
H
L
E
Y
F
E
E
A
V
N
Y
Rhesus Macaque
Macaca mulatta
XP_001091182
421
46346
K222
M
L
Q
H
P
Q
V
K
G
P
G
I
G
L
L
Dog
Lupus familis
XP_547892
445
48428
Y238
L
E
I
L
H
L
E
Y
F
E
E
A
V
N
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9QYR9
453
49634
Y248
I
E
T
M
H
M
E
Y
F
E
E
A
V
N
Y
Rat
Rattus norvegicus
O55171
453
49683
Y248
M
E
T
M
R
I
E
Y
F
E
E
A
V
N
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520078
421
46050
K222
L
R
K
H
P
Q
V
K
G
P
G
I
G
L
L
Chicken
Gallus gallus
XP_426429
461
50969
Y255
P
T
K
L
H
L
E
Y
F
E
E
A
V
N
Y
Frog
Xenopus laevis
NP_001084617
428
46458
Y223
M
K
H
F
H
L
E
Y
F
E
E
A
V
N
F
Zebra Danio
Brachydanio rerio
XP_696711
513
56999
Y299
A
D
R
F
H
L
E
Y
F
E
E
G
I
D
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001169107
421
46466
K222
M
L
Q
H
P
K
V
K
G
P
D
I
G
L
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
61.9
75.3
N.A.
68.7
70.1
N.A.
62.9
49.4
52.3
41.3
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.3
70.3
81.7
N.A.
79.9
79
N.A.
72.2
62.3
68.1
58.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
6.6
80
N.A.
73.3
73.3
N.A.
0
73.3
66.6
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
6.6
93.3
N.A.
100
93.3
N.A.
6.6
80
86.6
73.3
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
54.6
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
66.4
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
0
0
0
0
0
0
64
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
0
0
10
0
0
10
0
% D
% Glu:
0
46
0
0
0
0
73
0
0
73
73
0
0
0
0
% E
% Phe:
0
0
0
19
0
0
0
0
73
0
0
0
0
0
19
% F
% Gly:
0
0
0
0
0
0
0
0
28
0
19
10
28
0
0
% G
% His:
0
0
10
28
64
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
10
0
0
10
0
0
0
0
0
28
10
0
0
% I
% Lys:
0
10
19
0
0
10
0
28
0
0
0
0
0
0
0
% K
% Leu:
19
19
0
37
0
55
0
0
0
0
0
0
0
28
28
% L
% Met:
55
0
0
19
0
10
0
0
0
0
0
0
10
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
64
0
% N
% Pro:
10
0
0
0
28
0
0
0
0
28
0
0
0
0
0
% P
% Gln:
0
0
19
0
0
19
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
10
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
10
37
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
28
0
0
0
0
0
55
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
73
0
0
0
0
0
0
55
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _