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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS41 All Species: 34.55
Human Site: S446 Identified Species: 54.29
UniProt: P49754 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49754 NP_055211.2 854 98566 S446 I G Q L K A I S P Y L P R G D
Chimpanzee Pan troglodytes XP_519057 852 98261 S444 I G Q L K A I S P Y L P R G D
Rhesus Macaque Macaca mulatta XP_001101460 879 101397 S471 I G Q L K A I S P Y L P R G D
Dog Lupus familis XP_533084 854 98472 S446 I G Q L K A I S P Y L P R G D
Cat Felis silvestris
Mouse Mus musculus Q5KU39 853 98584 S445 I G Q L K A I S P Y L P R G D
Rat Rattus norvegicus NP_001100825 745 86357 E382 E E A L M A A E I S H R N I K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512356 1286 146402 S877 I G Q L K A I S P Y L P R G D
Chicken Gallus gallus NP_001012877 804 93396 E420 M V L H E F L E S D Y E G F A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_691671 854 99073 S446 I G Q L K A I S Q Y L P R G D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001036416 841 96907 S446 C Q Q L R S V S A Y L P T S D
Honey Bee Apis mellifera XP_624100 842 97559 S448 V H Q L R S I S S Y L P R G D
Nematode Worm Caenorhab. elegans Q19954 901 102561 A486 V K L C T L L A E V L P D G T
Sea Urchin Strong. purpuratus XP_797006 789 90527 W424 F N K L I K E W P H D L Y D L
Poplar Tree Populus trichocarpa XP_002313553 952 107269 Y485 Q L P V L V P Y M P T E N P R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93043 980 110260 Y488 Q L P V L V P Y M P T D N P R
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.5 97.7 N.A. 97.1 83.3 N.A. 61.1 86.7 N.A. 82.1 N.A. 37.8 43 28.1 50.2
Protein Similarity: 100 99.7 96.2 99.3 N.A. 99.3 85.8 N.A. 63.4 90.9 N.A. 89.9 N.A. 58.2 65.4 50.5 69.2
P-Site Identity: 100 100 100 100 N.A. 100 13.3 N.A. 100 0 N.A. 93.3 N.A. 46.6 66.6 20 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 100 20 N.A. 93.3 N.A. 66.6 86.6 40 26.6
Percent
Protein Identity: 35.7 N.A. N.A. 34.6 N.A. N.A.
Protein Similarity: 54.5 N.A. N.A. 52.8 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 54 7 7 7 0 0 0 0 0 7 % A
% Cys: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 7 7 7 7 7 60 % D
% Glu: 7 7 0 0 7 0 7 14 7 0 0 14 0 0 0 % E
% Phe: 7 0 0 0 0 7 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 47 0 0 0 0 0 0 0 0 0 0 7 60 0 % G
% His: 0 7 0 7 0 0 0 0 0 7 7 0 0 0 0 % H
% Ile: 47 0 0 0 7 0 54 0 7 0 0 0 0 7 0 % I
% Lys: 0 7 7 0 47 7 0 0 0 0 0 0 0 0 7 % K
% Leu: 0 14 14 74 14 7 14 0 0 0 67 7 0 0 7 % L
% Met: 7 0 0 0 7 0 0 0 14 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 0 0 0 0 0 0 20 0 0 % N
% Pro: 0 0 14 0 0 0 14 0 47 14 0 67 0 14 0 % P
% Gln: 14 7 60 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 14 0 0 0 0 0 0 7 54 0 14 % R
% Ser: 0 0 0 0 0 14 0 60 14 7 0 0 0 7 0 % S
% Thr: 0 0 0 0 7 0 0 0 0 0 14 0 7 0 7 % T
% Val: 14 7 0 14 0 14 7 0 0 7 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 7 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 14 0 60 7 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _