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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VPS41 All Species: 33.64
Human Site: Y448 Identified Species: 52.86
UniProt: P49754 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49754 NP_055211.2 854 98566 Y448 Q L K A I S P Y L P R G D P V
Chimpanzee Pan troglodytes XP_519057 852 98261 Y446 Q L K A I S P Y L P R G D P V
Rhesus Macaque Macaca mulatta XP_001101460 879 101397 Y473 Q L K A I S P Y L P R G D P V
Dog Lupus familis XP_533084 854 98472 Y448 Q L K A I S P Y L P R G D P I
Cat Felis silvestris
Mouse Mus musculus Q5KU39 853 98584 Y447 Q L K A I S P Y L P R G D P V
Rat Rattus norvegicus NP_001100825 745 86357 S384 A L M A A E I S H R N I K R H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512356 1286 146402 Y879 Q L K A I S P Y L P R G D P V
Chicken Gallus gallus NP_001012877 804 93396 D422 L H E F L E S D Y E G F A T L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_691671 854 99073 Y448 Q L K A I S Q Y L P R G D L R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001036416 841 96907 Y448 Q L R S V S A Y L P T S D E C
Honey Bee Apis mellifera XP_624100 842 97559 Y450 Q L R S I S S Y L P R G D V T
Nematode Worm Caenorhab. elegans Q19954 901 102561 V488 L C T L L A E V L P D G T P T
Sea Urchin Strong. purpuratus XP_797006 789 90527 H426 K L I K E W P H D L Y D L M T
Poplar Tree Populus trichocarpa XP_002313553 952 107269 P487 P V L V P Y M P T E N P R L R
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93043 980 110260 P490 P V L V P Y M P T D N P R L K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 95.5 97.7 N.A. 97.1 83.3 N.A. 61.1 86.7 N.A. 82.1 N.A. 37.8 43 28.1 50.2
Protein Similarity: 100 99.7 96.2 99.3 N.A. 99.3 85.8 N.A. 63.4 90.9 N.A. 89.9 N.A. 58.2 65.4 50.5 69.2
P-Site Identity: 100 100 100 93.3 N.A. 100 13.3 N.A. 100 0 N.A. 80 N.A. 46.6 66.6 26.6 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 100 20 N.A. 80 N.A. 66.6 80 40 26.6
Percent
Protein Identity: 35.7 N.A. N.A. 34.6 N.A. N.A.
Protein Similarity: 54.5 N.A. N.A. 52.8 N.A. N.A.
P-Site Identity: 0 N.A. N.A. 0 N.A. N.A.
P-Site Similarity: 6.6 N.A. N.A. 6.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 54 7 7 7 0 0 0 0 0 7 0 0 % A
% Cys: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 7 % C
% Asp: 0 0 0 0 0 0 0 7 7 7 7 7 60 0 0 % D
% Glu: 0 0 7 0 7 14 7 0 0 14 0 0 0 7 0 % E
% Phe: 0 0 0 7 0 0 0 0 0 0 0 7 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 7 60 0 0 0 % G
% His: 0 7 0 0 0 0 0 7 7 0 0 0 0 0 7 % H
% Ile: 0 0 7 0 54 0 7 0 0 0 0 7 0 0 7 % I
% Lys: 7 0 47 7 0 0 0 0 0 0 0 0 7 0 7 % K
% Leu: 14 74 14 7 14 0 0 0 67 7 0 0 7 20 7 % L
% Met: 0 0 7 0 0 0 14 0 0 0 0 0 0 7 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 20 0 0 0 0 % N
% Pro: 14 0 0 0 14 0 47 14 0 67 0 14 0 47 0 % P
% Gln: 60 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 14 0 0 0 0 0 0 7 54 0 14 7 14 % R
% Ser: 0 0 0 14 0 60 14 7 0 0 0 7 0 0 0 % S
% Thr: 0 0 7 0 0 0 0 0 14 0 7 0 7 7 20 % T
% Val: 0 14 0 14 7 0 0 7 0 0 0 0 0 7 34 % V
% Trp: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 14 0 60 7 0 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _