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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TMED10 All Species: 31.21
Human Site: S72 Identified Species: 45.78
UniProt: P49755 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49755 NP_006818.3 219 24976 S72 G G A G G L R S H L K I T D S
Chimpanzee Pan troglodytes XP_510074 371 40763 S224 G G A G G L R S H L K I T D S
Rhesus Macaque Macaca mulatta XP_001089815 336 37115 S189 G G A G G L R S H L K I T D S
Dog Lupus familis XP_854043 219 24762 T72 G G A G G L R T H L K I T D S
Cat Felis silvestris
Mouse Mus musculus Q9D1D4 219 24892 T72 G G A G G L R T H L K I T D S
Rat Rattus norvegicus Q63584 219 24839 T72 G G A G G L R T H L K I T D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506639 244 27530 T97 S G G A G I R T H L R I T D S
Chicken Gallus gallus NP_001006482 219 24785 A69 G S S S G P S A N L K I T D S
Frog Xenopus laevis NP_001090170 207 23927 K60 N Q G Q V R L K I T D S A G H
Zebra Danio Brachydanio rerio NP_999863 209 24423 T59 S E Q P N T K T N L K I T D S
Tiger Blowfish Takifugu rubipres Q90515 213 24635 S66 S T V V G D G S I F K I T D S
Fruit Fly Dros. melanogaster Q8SXY6 206 23673 A61 G Q I I D Y I A R D T K G H I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_505879 204 23662 E69 G H T L Y K R E N F A D L K G
Sea Urchin Strong. purpuratus XP_791690 154 18084 G26 T R E D A T E G K F A F T T D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P54837 211 24088 N63 V G D G Q K L N L F V R D S V
Red Bread Mold Neurospora crassa Q9HEK4 215 24521 N66 K G D G M N V N M H I S D S H
Conservation
Percent
Protein Identity: 100 58.7 64.2 94.9 N.A. 92.6 93.1 N.A. 67.2 80.8 78.5 79.4 78.5 53.4 N.A. 53.8 52
Protein Similarity: 100 58.7 64.5 96.3 N.A. 94.9 95.4 N.A. 74.5 84.4 84 86.3 84.4 66.2 N.A. 71.2 62.1
P-Site Identity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 60 53.3 0 40 46.6 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 80 73.3 0 60 46.6 13.3 N.A. 20 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 36.5 38.3
Protein Similarity: N.A. N.A. N.A. N.A. 56.1 57.9
P-Site Identity: N.A. N.A. N.A. N.A. 13.3 13.3
P-Site Similarity: N.A. N.A. N.A. N.A. 20 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 38 7 7 0 0 13 0 0 13 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 13 7 7 7 0 0 0 7 7 7 13 63 7 % D
% Glu: 0 7 7 0 0 0 7 7 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 25 0 7 0 0 0 % F
% Gly: 57 57 13 50 57 0 7 7 0 0 0 0 7 7 7 % G
% His: 0 7 0 0 0 0 0 0 44 7 0 0 0 7 13 % H
% Ile: 0 0 7 7 0 7 7 0 13 0 7 63 0 0 7 % I
% Lys: 7 0 0 0 0 13 7 7 7 0 57 7 0 7 0 % K
% Leu: 0 0 0 7 0 38 13 0 7 57 0 0 7 0 0 % L
% Met: 0 0 0 0 7 0 0 0 7 0 0 0 0 0 0 % M
% Asn: 7 0 0 0 7 7 0 13 19 0 0 0 0 0 0 % N
% Pro: 0 0 0 7 0 7 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 13 7 7 7 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 7 50 0 7 0 7 7 0 0 0 % R
% Ser: 19 7 7 7 0 0 7 25 0 0 0 13 0 13 63 % S
% Thr: 7 7 7 0 0 13 0 32 0 7 7 0 69 7 0 % T
% Val: 7 0 7 7 7 0 7 0 0 0 7 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 7 7 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _