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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RGS6
All Species:
52.73
Human Site:
S194
Identified Species:
89.23
UniProt:
P49758
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49758
NP_004287.3
472
54423
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Chimpanzee
Pan troglodytes
XP_001147276
490
56494
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Rhesus Macaque
Macaca mulatta
XP_001084681
472
54477
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Dog
Lupus familis
XP_537503
683
78241
S181
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2H2
472
54513
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Rat
Rattus norvegicus
P49803
477
55673
S191
I
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514330
608
70692
S191
I
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Chicken
Gallus gallus
XP_421174
472
54583
S194
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Frog
Xenopus laevis
NP_001079945
471
54554
S193
T
E
R
K
I
L
D
S
Q
E
R
G
F
W
D
Zebra Danio
Brachydanio rerio
NP_001030340
489
56551
S193
T
E
R
K
I
L
D
S
Q
E
R
A
F
W
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523380
647
70137
A371
A
E
S
Q
S
K
V
A
K
K
R
D
K
L
E
Honey Bee
Apis mellifera
XP_393403
510
59946
S237
L
E
R
K
V
L
D
S
Q
E
R
A
F
W
D
Nematode Worm
Caenorhab. elegans
P49809
555
63260
S191
Q
E
R
Q
I
L
D
S
Q
E
R
A
F
W
D
Sea Urchin
Strong. purpuratus
XP_782272
467
54702
S189
M
E
R
K
V
L
D
S
Q
E
R
A
F
W
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.3
98.9
64.4
N.A.
97.6
71.4
N.A.
57.2
92.8
87.2
79.1
N.A.
40.3
50.7
45.5
59.7
Protein Similarity:
100
96.3
99.5
65.7
N.A.
99.3
85.3
N.A.
67.5
94.4
92.5
87.7
N.A.
53.1
68.4
60.5
73.7
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
93.3
100
93.3
100
N.A.
13.3
86.6
86.6
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
93.3
N.A.
93.3
100
93.3
100
N.A.
46.6
93.3
93.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
8
0
0
0
86
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
93
0
0
0
0
8
0
0
93
% D
% Glu:
0
100
0
0
0
0
0
0
0
93
0
0
0
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
93
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
15
0
0
0
79
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
86
0
8
0
0
8
8
0
0
8
0
0
% K
% Leu:
8
0
0
0
0
93
0
0
0
0
0
0
0
8
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
8
0
0
15
0
0
0
0
93
0
0
0
0
0
0
% Q
% Arg:
0
0
93
0
0
0
0
0
0
0
100
0
0
0
0
% R
% Ser:
0
0
8
0
8
0
0
93
0
0
0
0
0
0
0
% S
% Thr:
58
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
15
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
93
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _