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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RGS6
All Species:
38.18
Human Site:
S232
Identified Species:
64.62
UniProt:
P49758
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49758
NP_004287.3
472
54423
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Chimpanzee
Pan troglodytes
XP_001147276
490
56494
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Rhesus Macaque
Macaca mulatta
XP_001084681
472
54477
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Dog
Lupus familis
XP_537503
683
78241
S219
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2H2
472
54513
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
D
E
Rat
Rattus norvegicus
P49803
477
55673
S229
N
P
H
K
T
R
K
S
V
Y
G
L
Q
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514330
608
70692
S229
N
P
H
K
T
R
K
S
V
Y
G
L
Q
N
D
Chicken
Gallus gallus
XP_421174
472
54583
S232
N
P
Q
K
V
K
K
S
V
Y
G
V
T
E
E
Frog
Xenopus laevis
NP_001079945
471
54554
S231
N
P
Q
K
V
K
K
S
V
Y
G
V
S
E
D
Zebra Danio
Brachydanio rerio
NP_001030340
489
56551
S231
N
P
Q
R
V
K
K
S
V
Y
G
V
V
D
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523380
647
70137
D406
C
V
N
T
T
E
I
D
I
K
K
A
Y
R
R
Honey Bee
Apis mellifera
XP_393403
510
59946
K272
R
T
Y
K
P
F
P
K
L
S
K
H
L
Q
L
Nematode Worm
Caenorhab. elegans
P49809
555
63260
I308
S
T
P
P
V
T
T
I
T
A
T
I
N
A
G
Sea Urchin
Strong. purpuratus
XP_782272
467
54702
R220
K
K
L
S
R
I
N
R
T
F
K
K
K
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.3
98.9
64.4
N.A.
97.6
71.4
N.A.
57.2
92.8
87.2
79.1
N.A.
40.3
50.7
45.5
59.7
Protein Similarity:
100
96.3
99.5
65.7
N.A.
99.3
85.3
N.A.
67.5
94.4
92.5
87.7
N.A.
53.1
68.4
60.5
73.7
P-Site Identity:
100
100
100
100
N.A.
93.3
53.3
N.A.
53.3
100
86.6
73.3
N.A.
0
6.6
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
73.3
N.A.
73.3
100
100
93.3
N.A.
13.3
20
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
0
8
0
8
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
0
0
0
0
15
29
% D
% Glu:
0
0
0
0
0
8
0
0
0
0
0
0
0
43
43
% E
% Phe:
0
0
0
0
0
8
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
72
0
0
0
8
% G
% His:
0
0
15
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
8
8
0
0
8
0
0
8
% I
% Lys:
8
8
0
72
0
58
72
8
0
8
22
8
8
8
0
% K
% Leu:
0
0
8
0
0
0
0
0
8
0
0
15
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
72
0
8
0
0
0
8
0
0
0
0
0
8
15
0
% N
% Pro:
0
72
8
8
8
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
58
0
0
0
0
0
0
0
0
0
15
8
0
% Q
% Arg:
8
0
0
8
8
15
0
8
0
0
0
0
0
8
8
% R
% Ser:
8
0
0
8
0
0
0
72
0
8
0
0
8
0
0
% S
% Thr:
0
15
0
8
22
8
8
0
15
0
8
0
43
0
0
% T
% Val:
0
8
0
0
65
0
0
0
72
0
0
58
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
72
0
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _