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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
RGS6
All Species:
30.3
Human Site:
S250
Identified Species:
51.28
UniProt:
P49758
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49758
NP_004287.3
472
54423
S250
Q
S
P
V
H
V
L
S
Q
P
I
R
K
T
T
Chimpanzee
Pan troglodytes
XP_001147276
490
56494
S250
Q
S
P
V
H
V
L
S
Q
P
I
R
K
T
T
Rhesus Macaque
Macaca mulatta
XP_001084681
472
54477
S250
Q
S
P
V
H
V
L
S
Q
P
I
R
K
T
T
Dog
Lupus familis
XP_537503
683
78241
S237
Q
S
P
V
H
I
P
S
Q
P
I
R
K
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z2H2
472
54513
S250
Q
S
P
V
H
I
P
S
Q
P
I
R
K
T
T
Rat
Rattus norvegicus
P49803
477
55673
T247
H
S
P
T
H
T
P
T
P
E
T
K
P
P
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514330
608
70692
L247
H
S
P
T
H
T
P
L
P
E
T
K
P
P
T
Chicken
Gallus gallus
XP_421174
472
54583
S250
Q
S
P
V
H
V
P
S
Q
P
V
R
K
T
T
Frog
Xenopus laevis
NP_001079945
471
54554
S249
Q
S
P
V
H
M
A
S
H
V
I
R
K
T
T
Zebra Danio
Brachydanio rerio
NP_001030340
489
56551
A249
Q
S
P
V
H
T
P
A
Q
Q
S
S
K
D
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523380
647
70137
G424
S
H
G
T
G
S
A
G
A
S
L
A
K
N
P
Honey Bee
Apis mellifera
XP_393403
510
59946
S290
N
T
D
I
P
S
H
S
E
S
Y
T
V
S
S
Nematode Worm
Caenorhab. elegans
P49809
555
63260
G326
N
N
Y
Y
T
R
P
G
L
R
R
C
T
Q
V
Sea Urchin
Strong. purpuratus
XP_782272
467
54702
S238
E
D
G
D
R
C
P
S
D
S
D
I
Q
S
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.3
98.9
64.4
N.A.
97.6
71.4
N.A.
57.2
92.8
87.2
79.1
N.A.
40.3
50.7
45.5
59.7
Protein Similarity:
100
96.3
99.5
65.7
N.A.
99.3
85.3
N.A.
67.5
94.4
92.5
87.7
N.A.
53.1
68.4
60.5
73.7
P-Site Identity:
100
100
100
86.6
N.A.
86.6
26.6
N.A.
26.6
86.6
73.3
53.3
N.A.
6.6
6.6
0
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
40
N.A.
33.3
93.3
80
60
N.A.
13.3
40
6.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
15
8
8
0
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
8
0
0
0
0
0
8
0
0
0
% C
% Asp:
0
8
8
8
0
0
0
0
8
0
8
0
0
8
0
% D
% Glu:
8
0
0
0
0
0
0
0
8
15
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
15
0
8
0
0
15
0
0
0
0
0
0
0
% G
% His:
15
8
0
0
72
0
8
0
8
0
0
0
0
0
0
% H
% Ile:
0
0
0
8
0
15
0
0
0
0
43
8
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
15
65
0
0
% K
% Leu:
0
0
0
0
0
0
22
8
8
0
8
0
0
0
0
% L
% Met:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% M
% Asn:
15
8
0
0
0
0
0
0
0
0
0
0
0
8
0
% N
% Pro:
0
0
72
0
8
0
58
0
15
43
0
0
15
15
8
% P
% Gln:
58
0
0
0
0
0
0
0
50
8
0
0
8
8
0
% Q
% Arg:
0
0
0
0
8
8
0
0
0
8
8
50
0
0
0
% R
% Ser:
8
72
0
0
0
15
0
65
0
22
8
8
0
15
8
% S
% Thr:
0
8
0
22
8
22
0
8
0
0
15
8
8
50
72
% T
% Val:
0
0
0
58
0
29
0
0
0
8
8
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
8
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _