Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLK1 All Species: 13.03
Human Site: S108 Identified Species: 23.89
UniProt: P49759 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49759 NP_004062.2 484 57291 S108 S S K S S G R S G R S S Y K S
Chimpanzee Pan troglodytes XP_001170873 484 57300 S108 S S K S S G R S G R S S Y K S
Rhesus Macaque Macaca mulatta XP_001093219 484 57330 S108 S S K S S G R S G R S S Y K S
Dog Lupus familis XP_531875 481 57271 S108 C S K S S V R S R R S S P K R
Cat Felis silvestris
Mouse Mus musculus P22518 483 57077 G108 S K S S G R S G R S S Y K S K
Rat Rattus norvegicus Q63117 490 58467 H108 Y R T R K H A H H C H K R R T
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513861 482 56823 H118 Y K K K F N F H R S S S H H S
Chicken Gallus gallus Q5ZIU3 526 59419 L109 G Y T E I Y F L G P N A K K R
Frog Xenopus laevis NP_001091432 462 54946 P109 H H S R H T S P S K S H R R K
Zebra Danio Brachydanio rerio NP_001038344 526 62655 R134 D R E D S Y R R K G S R R K H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P49762 832 95705 N426 Q S N S V I F N H S G Q Q H Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P51567 427 49548 Y98 G D D L T P R Y K I Y S K M G
Baker's Yeast Sacchar. cerevisiae P32350 737 83824 N148 L P S S S S I N N N N N I V T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 97.9 78.7 N.A. 89 50 N.A. 86.5 22.4 67.9 53.7 N.A. 31.8 N.A. N.A. N.A.
Protein Similarity: 100 100 98.7 86.7 N.A. 93.5 65.9 N.A. 91.7 39.1 79.1 68.2 N.A. 42.6 N.A. N.A. N.A.
P-Site Identity: 100 100 100 66.6 N.A. 20 0 N.A. 26.6 13.3 6.6 26.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 66.6 N.A. 20 13.3 N.A. 33.3 26.6 20 33.3 N.A. 20 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. 37.8 27.5 N.A.
Protein Similarity: N.A. N.A. N.A. 56.2 45 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 13.3 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 8 0 0 0 0 8 0 0 0 % A
% Cys: 8 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 8 8 8 8 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 8 8 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 8 0 24 0 0 0 0 0 0 0 0 % F
% Gly: 16 0 0 0 8 24 0 8 31 8 8 0 0 0 8 % G
% His: 8 8 0 0 8 8 0 16 16 0 8 8 8 16 8 % H
% Ile: 0 0 0 0 8 8 8 0 0 8 0 0 8 0 0 % I
% Lys: 0 16 39 8 8 0 0 0 16 8 0 8 24 47 16 % K
% Leu: 8 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 8 0 0 8 0 16 8 8 16 8 0 0 0 % N
% Pro: 0 8 0 0 0 8 0 8 0 8 0 0 8 0 0 % P
% Gln: 8 0 0 0 0 0 0 0 0 0 0 8 8 0 8 % Q
% Arg: 0 16 0 16 0 8 47 8 24 31 0 8 24 16 16 % R
% Ser: 31 39 24 54 47 8 16 31 8 24 62 47 0 8 31 % S
% Thr: 0 0 16 0 8 8 0 0 0 0 0 0 0 0 16 % T
% Val: 0 0 0 0 8 8 0 0 0 0 0 0 0 8 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 8 0 0 0 16 0 8 0 0 8 8 24 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _