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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK1
All Species:
16.36
Human Site:
S122
Identified Species:
30
UniProt:
P49759
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49759
NP_004062.2
484
57291
S122
S
K
H
R
I
H
H
S
T
S
H
R
R
S
H
Chimpanzee
Pan troglodytes
XP_001170873
484
57300
S122
S
K
H
R
I
H
H
S
T
S
H
R
R
S
H
Rhesus Macaque
Macaca mulatta
XP_001093219
484
57330
S122
S
K
H
R
I
H
H
S
T
S
H
R
R
S
H
Dog
Lupus familis
XP_531875
481
57271
S122
R
K
R
N
R
H
C
S
S
H
Q
S
R
S
K
Cat
Felis silvestris
Mouse
Mus musculus
P22518
483
57077
T122
K
H
R
S
R
H
H
T
S
Q
H
H
S
H
G
Rat
Rattus norvegicus
Q63117
490
58467
S122
T
R
S
C
S
S
A
S
S
R
S
Q
Q
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513861
482
56823
R132
S
H
T
K
S
H
R
R
K
R
S
R
S
V
E
Chicken
Gallus gallus
Q5ZIU3
526
59419
P123
R
Q
G
V
I
G
G
P
N
N
C
G
Y
D
D
Frog
Xenopus laevis
NP_001091432
462
54946
D123
K
R
S
R
S
V
E
D
D
E
E
G
H
L
I
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
T148
H
K
R
R
R
R
R
T
R
S
Y
S
A
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
N440
Q
P
H
Q
Q
Q
Q
N
E
M
S
K
S
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
V112
G
E
G
T
F
G
Q
V
L
E
C
W
D
R
E
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
G162
T
S
N
N
P
G
C
G
T
A
A
T
S
N
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.9
78.7
N.A.
89
50
N.A.
86.5
22.4
67.9
53.7
N.A.
31.8
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.7
86.7
N.A.
93.5
65.9
N.A.
91.7
39.1
79.1
68.2
N.A.
42.6
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
33.3
N.A.
20
13.3
N.A.
20
6.6
6.6
26.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
40
N.A.
33.3
46.6
N.A.
26.6
20
13.3
40
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
56.2
45
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
8
8
0
8
8
0
% A
% Cys:
0
0
0
8
0
0
16
0
0
0
16
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
8
0
0
0
8
8
8
% D
% Glu:
0
8
0
0
0
0
8
0
8
16
8
0
0
0
16
% E
% Phe:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
16
0
0
24
8
8
0
0
0
16
0
0
8
% G
% His:
8
16
31
0
0
47
31
0
0
8
31
8
8
8
24
% H
% Ile:
0
0
0
0
31
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
16
39
0
8
0
0
0
0
8
0
0
8
0
0
8
% K
% Leu:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
8
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
8
16
0
0
0
8
8
8
0
0
0
8
0
% N
% Pro:
0
8
0
0
8
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
8
8
0
8
8
8
16
0
0
8
8
8
8
0
0
% Q
% Arg:
16
16
24
39
24
8
16
8
8
16
0
31
31
8
0
% R
% Ser:
31
8
16
8
24
8
0
39
24
31
24
16
31
47
24
% S
% Thr:
16
0
8
8
0
0
0
16
31
0
0
8
0
0
0
% T
% Val:
0
0
0
8
0
8
0
8
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _