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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK1
All Species:
29.39
Human Site:
S442
Identified Species:
53.89
UniProt:
P49759
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49759
NP_004062.2
484
57291
S442
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
Chimpanzee
Pan troglodytes
XP_001170873
484
57300
S442
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
R
Rhesus Macaque
Macaca mulatta
XP_001093219
484
57330
S442
P
L
K
E
F
M
L
S
Q
D
V
E
H
E
C
Dog
Lupus familis
XP_531875
481
57271
C440
P
L
K
E
F
M
L
C
H
D
E
E
H
E
K
Cat
Felis silvestris
Mouse
Mus musculus
P22518
483
57077
S441
P
L
K
E
F
M
L
S
Q
D
A
E
H
E
F
Rat
Rattus norvegicus
Q63117
490
58467
Q437
P
L
K
S
Y
M
L
Q
D
S
L
E
H
V
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513861
482
56823
S439
P
L
K
E
F
M
L
S
Q
D
T
D
H
E
H
Chicken
Gallus gallus
Q5ZIU3
526
59419
S418
K
L
R
G
P
P
E
S
R
E
W
G
N
A
L
Frog
Xenopus laevis
NP_001091432
462
54946
S422
P
L
K
E
Y
M
V
S
D
N
K
D
H
H
Q
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
S468
P
L
R
R
Y
L
L
S
E
A
E
E
H
H
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
S764
P
L
F
L
C
Q
L
S
D
S
E
D
H
C
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
D390
N
L
I
M
Q
H
V
D
H
S
A
G
E
L
I
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
S635
D
R
L
D
I
Y
I
S
K
V
L
K
Q
D
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.9
78.7
N.A.
89
50
N.A.
86.5
22.4
67.9
53.7
N.A.
31.8
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.7
86.7
N.A.
93.5
65.9
N.A.
91.7
39.1
79.1
68.2
N.A.
42.6
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
73.3
N.A.
86.6
46.6
N.A.
80
13.3
46.6
40
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
80
N.A.
86.6
66.6
N.A.
86.6
40
80
73.3
N.A.
40
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
56.2
45
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
16
0
0
8
0
% A
% Cys:
0
0
0
0
8
0
0
8
0
0
0
0
0
8
8
% C
% Asp:
8
0
0
8
0
0
0
8
24
47
0
24
0
8
0
% D
% Glu:
0
0
0
54
0
0
8
0
8
8
24
54
8
47
8
% E
% Phe:
0
0
8
0
47
0
0
0
0
0
0
0
0
0
8
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
16
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
16
0
0
0
77
16
8
% H
% Ile:
0
0
8
0
8
0
8
0
0
0
0
0
0
0
8
% I
% Lys:
8
0
62
0
0
0
0
0
8
0
8
8
0
0
8
% K
% Leu:
0
93
8
8
0
8
70
0
0
0
16
0
0
8
8
% L
% Met:
0
0
0
8
0
62
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
8
0
0
8
0
0
% N
% Pro:
77
0
0
0
8
8
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
8
8
0
8
39
0
0
0
8
0
24
% Q
% Arg:
0
8
16
8
0
0
0
0
8
0
0
0
0
0
16
% R
% Ser:
0
0
0
8
0
0
0
77
0
24
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% T
% Val:
0
0
0
0
0
0
16
0
0
8
24
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
24
8
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _