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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK1
All Species:
17.88
Human Site:
T221
Identified Species:
32.78
UniProt:
P49759
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49759
NP_004062.2
484
57291
T221
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
Chimpanzee
Pan troglodytes
XP_001170873
484
57300
T221
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
Rhesus Macaque
Macaca mulatta
XP_001093219
484
57330
T221
N
T
T
D
P
N
S
T
F
R
C
V
Q
M
L
Dog
Lupus familis
XP_531875
481
57271
V219
N
S
T
D
P
N
S
V
F
R
C
V
Q
M
L
Cat
Felis silvestris
Mouse
Mus musculus
P22518
483
57077
T220
N
T
T
D
P
H
S
T
F
R
C
V
Q
M
L
Rat
Rattus norvegicus
Q63117
490
58467
K216
K
E
K
D
K
E
N
K
F
L
C
V
L
M
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513861
482
56823
T218
N
A
T
D
P
N
S
T
F
R
C
V
Q
M
L
Chicken
Gallus gallus
Q5ZIU3
526
59419
N206
R
K
Q
D
K
D
N
N
M
N
V
I
H
M
L
Frog
Xenopus laevis
NP_001091432
462
54946
C204
D
P
K
N
T
F
R
C
V
Q
M
L
E
W
F
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
N247
N
E
K
D
P
E
N
N
N
L
C
V
Q
M
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
D538
A
Q
K
D
P
H
C
D
H
L
C
V
K
M
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
R193
F
L
R
K
N
N
Y
R
S
F
P
I
D
L
V
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
Q373
L
N
N
D
P
Q
G
Q
F
Q
C
L
L
L
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.9
78.7
N.A.
89
50
N.A.
86.5
22.4
67.9
53.7
N.A.
31.8
N.A.
N.A.
N.A.
Protein Similarity:
100
100
98.7
86.7
N.A.
93.5
65.9
N.A.
91.7
39.1
79.1
68.2
N.A.
42.6
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
86.6
N.A.
93.3
33.3
N.A.
93.3
20
0
46.6
N.A.
33.3
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
40
N.A.
93.3
40
33.3
53.3
N.A.
53.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.8
27.5
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
56.2
45
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
8
8
0
0
77
0
0
0
0
% C
% Asp:
8
0
0
85
0
8
0
8
0
0
0
0
8
0
0
% D
% Glu:
0
16
0
0
0
16
0
0
0
0
0
0
8
0
0
% E
% Phe:
8
0
0
0
0
8
0
0
62
8
0
0
0
0
16
% F
% Gly:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
16
0
0
8
0
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
8
% I
% Lys:
8
8
31
8
16
0
0
8
0
0
0
0
8
0
0
% K
% Leu:
8
8
0
0
0
0
0
0
0
24
0
16
16
16
54
% L
% Met:
0
0
0
0
0
0
0
0
8
0
8
0
0
77
0
% M
% Asn:
54
8
8
8
8
47
24
16
8
8
0
0
0
0
0
% N
% Pro:
0
8
0
0
70
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
8
8
0
0
8
0
8
0
16
0
0
54
0
0
% Q
% Arg:
8
0
8
0
0
0
8
8
0
47
0
0
0
0
8
% R
% Ser:
0
8
0
0
0
0
47
0
8
0
0
0
0
0
8
% S
% Thr:
0
31
47
0
8
0
0
39
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
8
8
0
8
70
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _