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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK3
All Species:
9.7
Human Site:
T217
Identified Species:
17.78
UniProt:
P49761
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49761
NP_001123500.1
638
73515
T217
R
E
R
R
D
S
D
T
Y
R
C
E
E
R
S
Chimpanzee
Pan troglodytes
XP_001136940
490
58560
H111
R
K
H
A
H
H
C
H
K
R
R
T
R
S
C
Rhesus Macaque
Macaca mulatta
XP_001100690
638
73454
T217
R
E
R
R
D
S
D
T
Y
R
C
E
E
R
S
Dog
Lupus familis
XP_535541
381
44762
Cat
Felis silvestris
Mouse
Mus musculus
O35492
638
73779
T217
R
E
H
R
D
S
D
T
Y
R
C
E
E
R
S
Rat
Rattus norvegicus
Q63117
490
58467
H111
R
K
H
A
H
H
C
H
K
R
R
T
R
S
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012542
490
58745
R111
H
Q
H
Y
C
R
K
R
R
T
R
S
C
S
S
Frog
Xenopus laevis
NP_001093358
497
58599
K118
P
L
H
K
S
S
H
K
H
R
T
R
S
G
S
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
R147
K
H
K
R
R
R
R
R
T
R
S
Y
S
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
H361
Q
Q
Q
Q
Q
H
P
H
T
Q
F
Q
N
A
S
Honey Bee
Apis mellifera
XP_395279
439
51412
H60
R
A
R
I
Y
R
H
H
A
S
S
S
T
S
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
I48
C
G
Q
E
I
G
N
I
S
S
F
A
S
S
G
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
T217
I
V
P
R
V
T
Q
T
E
N
E
L
L
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.6
97.9
59.4
N.A.
88.8
76
N.A.
N.A.
65.8
53.2
51
N.A.
34
43.2
N.A.
N.A.
Protein Similarity:
100
76.6
98.2
59.5
N.A.
89.6
76.3
N.A.
N.A.
70.6
63.4
63.3
N.A.
49.8
53.9
N.A.
N.A.
P-Site Identity:
100
13.3
100
0
N.A.
93.3
13.3
N.A.
N.A.
6.6
20
20
N.A.
6.6
13.3
N.A.
N.A.
P-Site Similarity:
100
20
100
0
N.A.
93.3
20
N.A.
N.A.
13.3
33.3
33.3
N.A.
46.6
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.7
23.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
16
0
0
0
0
8
0
0
8
0
16
0
% A
% Cys:
8
0
0
0
8
0
16
0
0
0
24
0
8
0
16
% C
% Asp:
0
0
0
0
24
0
24
0
0
0
0
0
0
0
0
% D
% Glu:
0
24
0
8
0
0
0
0
8
0
8
24
24
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
0
0
0
0
0
0
0
8
8
% G
% His:
8
8
39
0
16
24
16
31
8
0
0
0
0
8
0
% H
% Ile:
8
0
0
8
8
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
8
16
8
8
0
0
8
8
16
0
0
0
0
0
0
% K
% Leu:
0
8
0
0
0
0
0
0
0
0
0
8
8
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
0
% N
% Pro:
8
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
8
16
16
8
8
0
8
0
0
8
0
8
0
0
8
% Q
% Arg:
47
0
24
39
8
24
8
16
8
54
24
8
16
24
0
% R
% Ser:
0
0
0
0
8
31
0
0
8
16
16
16
24
39
54
% S
% Thr:
0
0
0
0
0
8
0
31
16
8
8
16
8
0
0
% T
% Val:
0
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
0
0
24
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _