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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CLK3
All Species:
8.79
Human Site:
T251
Identified Species:
16.11
UniProt:
P49761
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49761
NP_001123500.1
638
73515
T251
R
E
R
G
P
Y
R
T
R
K
H
A
H
H
C
Chimpanzee
Pan troglodytes
XP_001136940
490
58560
V145
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Rhesus Macaque
Macaca mulatta
XP_001100690
638
73454
T251
R
E
R
G
P
Y
R
T
R
K
H
A
H
H
C
Dog
Lupus familis
XP_535541
381
44762
V36
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Cat
Felis silvestris
Mouse
Mus musculus
O35492
638
73779
T251
R
E
R
A
P
Y
R
T
R
K
H
A
H
H
C
Rat
Rattus norvegicus
Q63117
490
58467
V145
D
D
K
E
G
H
L
V
C
R
I
G
D
W
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001012542
490
58745
I145
E
G
H
L
V
C
R
I
G
D
W
L
Q
E
R
Frog
Xenopus laevis
NP_001093358
497
58599
R152
K
E
G
H
L
V
C
R
T
G
E
R
I
Q
E
Zebra Danio
Brachydanio rerio
NP_001038344
526
62655
D181
H
L
I
C
R
S
G
D
V
L
Q
E
R
Y
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P49762
832
95705
A395
Q
L
F
Y
A
S
P
A
S
S
S
S
N
K
Q
Honey Bee
Apis mellifera
XP_395279
439
51412
H94
V
E
D
D
E
D
G
H
L
V
Y
Q
S
G
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P51567
427
49548
K82
P
P
W
R
E
D
D
K
D
G
H
Y
I
F
E
Baker's Yeast
Sacchar. cerevisiae
P32350
737
83824
N251
H
S
T
S
P
F
S
N
P
P
A
Q
I
A
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
76.6
97.9
59.4
N.A.
88.8
76
N.A.
N.A.
65.8
53.2
51
N.A.
34
43.2
N.A.
N.A.
Protein Similarity:
100
76.6
98.2
59.5
N.A.
89.6
76.3
N.A.
N.A.
70.6
63.4
63.3
N.A.
49.8
53.9
N.A.
N.A.
P-Site Identity:
100
0
100
0
N.A.
93.3
0
N.A.
N.A.
6.6
6.6
0
N.A.
0
6.6
N.A.
N.A.
P-Site Similarity:
100
26.6
100
26.6
N.A.
93.3
26.6
N.A.
N.A.
6.6
13.3
6.6
N.A.
20
13.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
30.7
23.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
41.7
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
8
0
0
8
0
0
8
24
0
8
0
% A
% Cys:
0
0
0
8
0
8
8
0
24
0
0
0
0
0
24
% C
% Asp:
24
24
8
8
0
16
8
8
8
8
0
0
24
0
8
% D
% Glu:
8
39
0
24
16
0
0
0
0
0
8
8
0
8
24
% E
% Phe:
0
0
8
0
0
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
8
8
16
24
0
16
0
8
16
0
24
0
8
0
% G
% His:
16
0
8
8
0
24
0
8
0
0
31
0
24
24
0
% H
% Ile:
0
0
8
0
0
0
0
8
0
0
24
0
24
0
0
% I
% Lys:
8
0
24
0
0
0
0
8
0
24
0
0
0
8
0
% K
% Leu:
0
16
0
8
8
0
24
0
8
8
0
8
0
0
24
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
0
8
0
0
% N
% Pro:
8
8
0
0
31
0
8
0
8
8
0
0
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
0
0
8
16
8
8
8
% Q
% Arg:
24
0
24
8
8
0
31
8
24
24
0
8
8
0
8
% R
% Ser:
0
8
0
8
0
16
8
0
8
8
8
8
8
0
8
% S
% Thr:
0
0
8
0
0
0
0
24
8
0
0
0
0
0
0
% T
% Val:
8
0
0
0
8
8
0
24
8
8
0
0
0
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
8
0
0
24
0
% W
% Tyr:
0
0
0
8
0
24
0
0
0
0
8
8
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _