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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN1
All Species:
13.94
Human Site:
S23
Identified Species:
23.59
UniProt:
P49768
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49768
NP_000012.1
467
52668
S23
M
S
E
D
N
H
L
S
N
T
V
R
S
Q
N
Chimpanzee
Pan troglodytes
XP_001149972
443
50485
M16
S
Y
F
Q
N
A
Q
M
S
E
D
N
H
L
S
Rhesus Macaque
Macaca mulatta
XP_001088524
384
43068
Dog
Lupus familis
XP_547503
717
78133
I239
T
P
G
S
A
A
Q
I
P
P
V
T
V
R
S
Cat
Felis silvestris
Mouse
Mus musculus
P49769
467
52621
S23
M
S
E
D
S
H
S
S
S
A
I
R
S
Q
N
Rat
Rattus norvegicus
P97887
468
52771
S23
M
S
E
D
S
H
S
S
S
V
R
S
Q
N
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
S28
M
S
A
E
S
P
T
S
R
S
Y
Q
D
G
T
Chicken
Gallus gallus
Q4JIM4
468
52812
H24
T
E
N
F
P
D
N
H
L
S
N
T
N
D
N
Frog
Xenopus laevis
O12976
433
48282
Zebra Danio
Brachydanio rerio
Q9W6T7
456
50963
T23
G
M
D
T
S
R
H
T
S
S
T
A
A
P
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
Y45
R
Q
Q
Q
R
N
N
Y
G
S
S
N
Q
D
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
T17
G
G
G
A
D
A
E
T
H
T
V
Y
G
T
N
Sea Urchin
Strong. purpuratus
XP_001178715
518
58077
S56
R
P
I
Q
V
E
G
S
N
N
P
S
Y
G
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O64668
453
49290
C23
V
M
A
P
V
S
I
C
M
F
L
V
V
L
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
89.7
82.2
46.2
N.A.
92.7
92.5
N.A.
62.3
82.2
77.3
70.8
N.A.
47.6
N.A.
49
55.6
Protein Similarity:
100
90.7
82.2
52
N.A.
96.5
96.5
N.A.
73.6
89.7
83
79
N.A.
63.4
N.A.
64
68.1
P-Site Identity:
100
6.6
0
6.6
N.A.
66.6
40
N.A.
20
6.6
0
0
N.A.
0
N.A.
20
13.3
P-Site Similarity:
100
20
0
20
N.A.
86.6
60
N.A.
46.6
20
0
40
N.A.
20
N.A.
40
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
20.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
38.5
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
8
8
22
0
0
0
8
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
22
8
8
0
0
0
0
8
0
8
15
8
% D
% Glu:
0
8
22
8
0
8
8
0
0
8
0
0
0
0
0
% E
% Phe:
0
0
8
8
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
15
8
15
0
0
0
8
0
8
0
0
0
8
15
0
% G
% His:
0
0
0
0
0
22
8
8
8
0
0
0
8
0
0
% H
% Ile:
0
0
8
0
0
0
8
8
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
8
0
8
0
8
0
0
15
8
% L
% Met:
29
15
0
0
0
0
0
8
8
0
0
0
0
0
0
% M
% Asn:
0
0
8
0
15
8
15
0
15
8
8
15
8
8
29
% N
% Pro:
0
15
0
8
8
8
0
0
8
8
8
0
0
8
8
% P
% Gln:
0
8
8
22
0
0
15
0
0
0
0
8
15
15
8
% Q
% Arg:
15
0
0
0
8
8
0
0
8
0
8
15
0
8
0
% R
% Ser:
8
29
0
8
29
8
15
36
29
29
8
15
15
0
15
% S
% Thr:
15
0
0
8
0
0
8
15
0
15
8
15
0
8
15
% T
% Val:
8
0
0
0
15
0
0
0
0
8
22
8
15
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
0
0
0
0
0
8
0
0
8
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _