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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
41.82
Human Site:
S275
Identified Species:
70.77
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Chimpanzee
Pan troglodytes
XP_510071
351
38922
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Dog
Lupus familis
XP_547911
351
38990
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
S275
C
A
P
M
F
K
L
S
P
Q
F
P
S
E
E
Rat
Rattus norvegicus
Q62818
351
38857
S275
C
A
P
M
F
K
L
S
P
Q
F
P
S
E
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
S275
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Frog
Xenopus laevis
NP_001080268
305
34202
N230
F
A
V
M
S
R
V
N
K
F
P
N
E
E
D
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
S279
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
D
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
S279
C
A
P
M
F
K
L
S
P
Q
F
P
N
E
E
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
S277
L
A
P
M
Y
K
L
S
P
L
H
L
C
E
Q
Honey Bee
Apis mellifera
XP_393835
353
39514
S274
L
L
P
L
Y
K
L
S
P
L
Y
L
Y
S
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
L229
A
I
G
G
T
H
A
L
A
L
A
A
K
H
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
L301
A
V
A
G
L
Y
K
L
S
P
L
Y
P
F
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
100
20
93.3
100
53.3
33.3
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
46.6
100
100
66.6
53.3
N.A.
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
15
79
8
0
0
0
8
0
8
0
8
8
0
0
0
% A
% Cys:
65
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
22
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
8
79
58
% E
% Phe:
8
0
0
0
65
0
0
0
0
8
65
0
0
8
0
% F
% Gly:
0
0
8
15
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
8
0
0
8
15
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
79
8
0
8
0
0
0
8
0
0
% K
% Leu:
15
8
0
8
8
0
79
15
0
22
8
15
0
0
0
% L
% Met:
0
0
0
79
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
8
0
0
0
8
50
0
0
% N
% Pro:
0
0
79
0
0
0
0
0
79
8
8
65
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
65
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
8
0
0
79
8
0
0
0
15
8
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
8
8
0
0
0
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
15
8
0
0
0
0
8
8
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _