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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B2 All Species: 23.03
Human Site: S30 Identified Species: 38.97
UniProt: P49770 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49770 NP_055054.1 351 38990 S30 K R G G G P R S S E E M A R E
Chimpanzee Pan troglodytes XP_510071 351 38922 S30 K R G G G P R S S E E M A R E
Rhesus Macaque Macaca mulatta XP_001096471 351 38950 S30 K R G G G P R S S E E M A R E
Dog Lupus familis XP_547911 351 38990 S30 K R D G G R R S S E D M A R E
Cat Felis silvestris
Mouse Mus musculus Q99LD9 351 38879 S30 K R G G G Q R S S E D M A R E
Rat Rattus norvegicus Q62818 351 38857 T30 K R G G G R R T S E D M A R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006481 351 39055 R30 R G G G Q R P R S E D T A R Q
Frog Xenopus laevis NP_001080268 305 34202 S9 P G I T E K E S E L S E R I E
Zebra Danio Brachydanio rerio NP_998068 355 39340 G33 S G S G S L R G S V E T A R E
Tiger Blowfish Takifugu rubipres Q90511 355 39111 G33 S G T G P L R G S S E T A R E
Fruit Fly Dros. melanogaster NP_570020 352 39136 T31 S Y N I T N K T L D I F K Y I
Honey Bee Apis mellifera XP_393835 353 39514 N30 G D I K G I Y N I V V A T V V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001202427 304 33432 V8 S V K G S Y D V A H S T L S L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32502 381 42551 G36 L K R R Q V Q G S Y A I A L E
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 99.1 94.8 N.A. 94 92.8 N.A. N.A. 84.6 68.3 80.2 79.7 47.7 54.1 N.A. 54.4
Protein Similarity: 100 99.4 99.4 97.1 N.A. 98.2 97.7 N.A. N.A. 92 77.4 88.1 89 67 70.8 N.A. 69.8
P-Site Identity: 100 100 100 80 N.A. 86.6 80 N.A. N.A. 40 13.3 46.6 46.6 0 6.6 N.A. 6.6
P-Site Similarity: 100 100 100 86.6 N.A. 93.3 93.3 N.A. N.A. 60 13.3 46.6 46.6 20 13.3 N.A. 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 53.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 40 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 8 0 8 8 72 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 8 0 0 0 8 0 0 8 29 0 0 0 0 % D
% Glu: 0 0 0 0 8 0 8 0 8 50 36 8 0 0 72 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % F
% Gly: 8 29 43 72 50 0 0 22 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 0 15 8 0 8 0 0 8 0 8 8 0 8 8 % I
% Lys: 43 8 8 8 0 8 8 0 0 0 0 0 8 0 0 % K
% Leu: 8 0 0 0 0 15 0 0 8 8 0 0 8 8 8 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 43 0 0 0 % M
% Asn: 0 0 8 0 0 8 0 8 0 0 0 0 0 0 0 % N
% Pro: 8 0 0 0 8 22 8 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 15 8 8 0 0 0 0 0 0 0 8 % Q
% Arg: 8 43 8 8 0 22 58 8 0 0 0 0 8 65 0 % R
% Ser: 29 0 8 0 15 0 0 43 72 8 15 0 0 8 0 % S
% Thr: 0 0 8 8 8 0 0 15 0 0 0 29 8 0 0 % T
% Val: 0 8 0 0 0 8 0 8 0 15 8 0 0 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 8 8 0 0 8 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _