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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
36.36
Human Site:
S341
Identified Species:
61.54
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Chimpanzee
Pan troglodytes
XP_510071
351
38922
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Dog
Lupus familis
XP_547911
351
38990
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Rat
Rattus norvegicus
Q62818
351
38857
S341
S
Y
V
Y
R
L
M
S
E
L
Y
H
P
D
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
S341
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
D
D
Frog
Xenopus laevis
NP_001080268
305
34202
E296
Y
I
Y
R
L
M
S
E
L
Y
H
P
S
D
H
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
S345
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
E
D
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
S345
S
Y
I
Y
R
L
M
S
E
L
Y
H
P
E
D
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
E343
Y
V
Y
R
L
L
T
E
L
Y
H
P
E
D
L
Honey Bee
Apis mellifera
XP_393835
353
39514
R340
N
A
P
S
Y
I
Y
R
L
L
S
E
L
Y
H
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
P295
P
V
F
D
Y
V
P
P
E
L
V
T
L
F
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
D367
F
I
Y
R
I
A
W
D
N
Y
K
Q
I
D
V
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
100
100
N.A.
100
93.3
N.A.
N.A.
100
6.6
93.3
93.3
13.3
6.6
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
20
100
100
20
20
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
8
0
0
0
0
0
72
65
% D
% Glu:
0
0
0
0
0
0
0
15
72
0
0
8
8
15
0
% E
% Phe:
8
0
8
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
15
65
0
0
15
% H
% Ile:
0
15
58
0
8
8
0
0
0
0
0
0
8
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% K
% Leu:
0
0
0
0
15
72
0
0
22
79
0
0
15
0
8
% L
% Met:
0
0
0
0
0
8
65
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% N
% Pro:
8
0
8
0
0
0
8
8
0
0
0
15
65
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% Q
% Arg:
0
0
0
22
65
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
65
0
0
8
0
0
8
65
0
0
8
0
8
0
0
% S
% Thr:
0
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% T
% Val:
0
15
8
0
0
8
0
0
0
0
8
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
15
65
22
65
15
0
8
0
0
22
65
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _