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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
43.33
Human Site:
T238
Identified Species:
73.33
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Chimpanzee
Pan troglodytes
XP_510071
351
38922
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Dog
Lupus familis
XP_547911
351
38990
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
S
L
Rat
Rattus norvegicus
Q62818
351
38857
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
T238
K
V
I
I
G
T
K
T
I
L
A
N
G
A
L
Frog
Xenopus laevis
NP_001080268
305
34202
E193
K
F
H
V
I
V
A
E
C
A
P
F
C
Q
G
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
T242
K
V
I
I
G
T
Q
T
V
L
A
N
G
G
L
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
T242
K
V
I
I
G
T
Q
T
V
L
A
N
G
G
L
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
S240
K
V
I
I
G
T
H
S
V
L
A
N
G
G
L
Honey Bee
Apis mellifera
XP_393835
353
39514
T237
K
V
I
I
A
T
H
T
V
M
A
N
G
G
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
I192
H
D
I
E
T
T
V
I
T
D
S
A
V
F
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
A264
K
V
I
I
G
T
K
A
V
F
V
N
G
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
100
6.6
80
80
73.3
66.6
N.A.
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
13.3
93.3
93.3
86.6
80
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
8
8
0
8
79
8
0
36
8
% A
% Cys:
0
0
0
0
0
0
0
0
8
0
0
0
8
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
0
8
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
0
8
0
8
0
8
0
% F
% Gly:
0
0
0
0
79
0
0
0
0
0
0
0
86
36
8
% G
% His:
8
0
8
0
0
0
15
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
93
86
8
0
0
8
50
0
0
0
0
0
0
% I
% Lys:
93
0
0
0
0
0
58
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
72
0
0
0
0
79
% L
% Met:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
86
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
15
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
8
0
0
8
0
0
15
0
% S
% Thr:
0
0
0
0
8
93
0
72
8
0
0
0
0
0
8
% T
% Val:
0
86
0
8
0
8
8
0
36
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _