Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: EIF2B2 All Species: 34.85
Human Site: T298 Identified Species: 58.97
UniProt: P49770 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49770 NP_055054.1 351 38990 T298 P E E V L P F T E G D I L E K
Chimpanzee Pan troglodytes XP_510071 351 38922 T298 P E E V L P F T E G D I L E K
Rhesus Macaque Macaca mulatta XP_001096471 351 38950 T298 P E E V L P F T E G D I L E K
Dog Lupus familis XP_547911 351 38990 T298 P E E V L P F T E G D I L E K
Cat Felis silvestris
Mouse Mus musculus Q99LD9 351 38879 T298 P E E V L P F T E G D I L E K
Rat Rattus norvegicus Q62818 351 38857 T298 P E E V L P F T E G D I L E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006481 351 39055 T298 P Q E V L P F T E G E I L A K
Frog Xenopus laevis NP_001080268 305 34202 E253 Q E V L P F S E G E I L S Q V
Zebra Danio Brachydanio rerio NP_998068 355 39340 T302 P H E V L P F T E G E I L S K
Tiger Blowfish Takifugu rubipres Q90511 355 39111 T302 P H E V L P F T E G E I L S K
Fruit Fly Dros. melanogaster NP_570020 352 39136 D300 A E D V I P Y D S I P A R E A
Honey Bee Apis mellifera XP_393835 353 39514 I297 V S P L E G V I D D A N V T L
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001202427 304 33432 E252 P M F K L S P E Y L C S I D Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P32502 381 42551 R324 G S Q R I L P R M D P R K R L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 99.1 94.8 N.A. 94 92.8 N.A. N.A. 84.6 68.3 80.2 79.7 47.7 54.1 N.A. 54.4
Protein Similarity: 100 99.4 99.4 97.1 N.A. 98.2 97.7 N.A. N.A. 92 77.4 88.1 89 67 70.8 N.A. 69.8
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. N.A. 80 6.6 80 80 26.6 0 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. N.A. 93.3 26.6 86.6 86.6 46.6 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. 32 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 53.5 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 0 0 0 0 0 0 0 8 8 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 0 % C
% Asp: 0 0 8 0 0 0 0 8 8 15 43 0 0 8 0 % D
% Glu: 0 58 65 0 8 0 0 15 65 8 22 0 0 50 0 % E
% Phe: 0 0 8 0 0 8 65 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 0 8 0 0 8 65 0 0 0 0 0 % G
% His: 0 15 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 15 0 0 8 0 8 8 65 8 0 0 % I
% Lys: 0 0 0 8 0 0 0 0 0 0 0 0 8 0 65 % K
% Leu: 0 0 0 15 72 8 0 0 0 8 0 8 65 0 15 % L
% Met: 0 8 0 0 0 0 0 0 8 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 72 0 8 0 8 72 15 0 0 0 15 0 0 0 0 % P
% Gln: 8 8 8 0 0 0 0 0 0 0 0 0 0 8 8 % Q
% Arg: 0 0 0 8 0 0 0 8 0 0 0 8 8 8 0 % R
% Ser: 0 15 0 0 0 8 8 0 8 0 0 8 8 15 0 % S
% Thr: 0 0 0 0 0 0 0 65 0 0 0 0 0 8 0 % T
% Val: 8 0 8 72 0 0 8 0 0 0 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _