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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
21.52
Human Site:
Y126
Identified Species:
36.41
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
Y126
N
E
D
F
S
F
H
Y
A
Q
L
Q
S
N
I
Chimpanzee
Pan troglodytes
XP_510071
351
38922
Y126
N
E
D
F
S
F
H
Y
A
Q
L
Q
S
N
I
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
Y126
N
E
D
F
S
F
H
Y
A
Q
L
H
S
N
I
Dog
Lupus familis
XP_547911
351
38990
Y126
S
E
D
F
S
F
H
Y
A
Q
L
Q
S
N
I
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
F126
S
E
D
F
S
F
H
F
A
P
L
K
A
N
I
Rat
Rattus norvegicus
Q62818
351
38857
Y126
S
E
D
F
S
F
H
Y
A
P
L
K
S
N
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
Y126
S
E
D
F
S
T
P
Y
P
S
L
R
A
N
V
Frog
Xenopus laevis
NP_001080268
305
34202
E102
R
L
H
G
F
S
E
E
N
D
Q
Q
E
S
L
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
H129
S
E
D
N
F
R
Q
H
F
A
H
L
K
A
N
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
H129
S
E
E
N
F
R
Q
H
F
A
A
L
R
A
N
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
Q126
S
V
D
Y
S
V
P
Q
H
G
L
R
E
A
L
Honey Bee
Apis mellifera
XP_393835
353
39514
S124
Q
Q
V
D
F
N
I
S
V
P
S
L
K
S
A
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
C101
V
E
D
F
S
K
P
C
M
N
L
K
G
R
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
H132
L
Q
K
P
E
Q
P
H
Q
N
R
K
N
S
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
93.3
93.3
N.A.
66.6
80
N.A.
N.A.
46.6
6.6
13.3
6.6
20
0
N.A.
33.3
P-Site Similarity:
100
100
93.3
100
N.A.
93.3
93.3
N.A.
N.A.
73.3
20
26.6
26.6
46.6
13.3
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
43
15
8
0
15
22
8
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
72
8
0
0
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
72
8
0
8
0
8
8
0
0
0
0
15
0
0
% E
% Phe:
0
0
0
58
29
43
0
8
15
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
0
8
0
0
8
0
0
% G
% His:
0
0
8
0
0
0
43
22
8
0
8
8
0
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
43
% I
% Lys:
0
0
8
0
0
8
0
0
0
0
0
29
15
0
0
% K
% Leu:
8
8
0
0
0
0
0
0
0
0
65
22
0
0
15
% L
% Met:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
22
0
0
15
0
8
0
0
8
15
0
0
8
50
15
% N
% Pro:
0
0
0
8
0
0
29
0
8
22
0
0
0
0
0
% P
% Gln:
8
15
0
0
0
8
15
8
8
29
8
29
0
0
0
% Q
% Arg:
8
0
0
0
0
15
0
0
0
0
8
15
8
8
0
% R
% Ser:
50
0
0
0
65
8
0
8
0
8
8
0
36
22
15
% S
% Thr:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% T
% Val:
8
8
8
0
0
8
0
0
8
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
0
0
43
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _