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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
36.06
Human Site:
Y315
Identified Species:
61.03
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Chimpanzee
Pan troglodytes
XP_510071
351
38922
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Dog
Lupus familis
XP_547911
351
38990
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
Y315
V
H
C
P
V
F
D
Y
V
P
P
D
L
I
T
Rat
Rattus norvegicus
Q62818
351
38857
Y315
V
H
C
P
V
F
D
Y
V
P
P
D
L
I
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
Y315
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Frog
Xenopus laevis
NP_001080268
305
34202
V270
Y
C
P
I
F
D
H
V
P
P
E
L
I
T
L
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
Y319
A
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
Y319
V
H
C
P
V
F
D
Y
V
P
P
E
L
I
T
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
V317
Y
S
P
M
F
D
Y
V
P
P
E
L
V
T
L
Honey Bee
Apis mellifera
XP_393835
353
39514
V314
K
I
H
V
Y
N
P
V
F
D
Y
V
P
P
E
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
K269
F
N
K
F
E
S
P
K
E
I
L
D
Y
S
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
V341
V
N
Q
I
T
D
Y
V
P
P
E
N
I
D
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
100
100
N.A.
93.3
93.3
N.A.
N.A.
100
6.6
93.3
100
6.6
0
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
13.3
93.3
100
13.3
0
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
8
65
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
22
65
0
0
8
0
22
0
8
8
% D
% Glu:
0
0
0
0
8
0
0
0
8
0
22
50
0
0
8
% E
% Phe:
8
0
0
8
15
65
0
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
65
8
0
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
8
0
15
0
0
0
0
0
8
0
0
15
65
8
% I
% Lys:
8
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
15
65
0
15
% L
% Met:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
15
0
0
0
8
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
15
65
0
0
15
0
22
86
65
0
8
8
0
% P
% Gln:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
8
0
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
0
0
8
0
0
0
0
0
0
0
0
15
65
% T
% Val:
65
0
0
8
65
0
0
29
65
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
0
0
0
8
0
15
65
0
0
8
0
8
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _