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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B2
All Species:
36.36
Human Site:
Y93
Identified Species:
61.54
UniProt:
P49770
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49770
NP_055054.1
351
38990
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Chimpanzee
Pan troglodytes
XP_510071
351
38922
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Rhesus Macaque
Macaca mulatta
XP_001096471
351
38950
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Dog
Lupus familis
XP_547911
351
38990
Y93
L
R
I
I
R
E
E
Y
G
R
L
H
G
R
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99LD9
351
38879
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Rat
Rattus norvegicus
Q62818
351
38857
Y93
L
K
I
I
R
E
E
Y
G
R
L
H
G
R
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001006481
351
39055
Y93
L
K
V
I
R
E
E
Y
G
R
L
H
G
R
S
Frog
Xenopus laevis
NP_001080268
305
34202
T69
R
R
E
G
R
R
M
T
A
A
Q
P
S
E
T
Zebra Danio
Brachydanio rerio
NP_998068
355
39340
Y96
L
K
I
I
R
E
E
Y
A
R
S
R
G
S
S
Tiger Blowfish
Takifugu rubipres
Q90511
355
39111
Y96
L
K
I
I
R
E
E
Y
A
R
S
R
G
S
S
Fruit Fly
Dros. melanogaster
NP_570020
352
39136
V93
F
D
L
L
H
A
K
V
Q
H
F
A
D
D
S
Honey Bee
Apis mellifera
XP_393835
353
39514
T91
Q
I
I
R
E
E
Y
T
S
E
L
K
N
K
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202427
304
33432
A68
K
I
I
R
E
E
Y
A
R
W
G
Q
G
V
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32502
381
42551
V99
L
A
V
L
R
D
E
V
E
E
D
T
M
S
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
99.1
94.8
N.A.
94
92.8
N.A.
N.A.
84.6
68.3
80.2
79.7
47.7
54.1
N.A.
54.4
Protein Similarity:
100
99.4
99.4
97.1
N.A.
98.2
97.7
N.A.
N.A.
92
77.4
88.1
89
67
70.8
N.A.
69.8
P-Site Identity:
100
100
100
93.3
N.A.
100
100
N.A.
N.A.
93.3
6.6
73.3
73.3
6.6
20
N.A.
20
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
20
73.3
73.3
26.6
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
32
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
53.5
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
0
8
22
8
0
8
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
8
0
0
0
0
8
0
8
8
8
% D
% Glu:
0
0
8
0
15
79
72
0
8
15
0
0
0
8
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
0
0
50
0
8
0
72
0
0
% G
% His:
0
0
0
0
8
0
0
0
0
8
0
50
0
0
0
% H
% Ile:
0
15
72
65
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
8
58
0
0
0
0
8
0
0
0
0
8
0
8
0
% K
% Leu:
72
0
8
15
0
0
0
0
0
0
58
0
0
0
0
% L
% Met:
0
0
0
0
0
0
8
0
0
0
0
0
8
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
8
0
0
0
0
0
0
0
8
0
8
8
0
0
0
% Q
% Arg:
8
15
0
15
79
8
0
0
8
65
0
15
0
50
0
% R
% Ser:
0
0
0
0
0
0
0
0
8
0
15
0
8
22
72
% S
% Thr:
0
0
0
0
0
0
0
15
0
0
0
8
0
0
15
% T
% Val:
0
0
15
0
0
0
0
15
0
0
0
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
15
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _