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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSEN2 All Species: 28.79
Human Site: S19 Identified Species: 48.72
UniProt: P49810 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49810 NP_000438.2 448 50140 S19 E V C D E R T S L M S A E S P
Chimpanzee Pan troglodytes XP_514247 448 50096 S19 E V C D E R T S L M S A E S P
Rhesus Macaque Macaca mulatta XP_001087264 654 71396 S225 E V C D E R T S L M S A E S P
Dog Lupus familis XP_547503 717 78133 S288 E V C D E R T S L M S A E S P
Cat Felis silvestris
Mouse Mus musculus Q61144 448 49965 S19 E V C D E R T S L M S A E S P
Rat Rattus norvegicus O88777 448 50033 S19 E V C D E R T S L M S A E S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514754 455 50711 S19 E V C N E R T S L M S A E S P
Chicken Gallus gallus Q90X07 451 50448 E25 R T S L M S A E S P P V P S Y
Frog Xenopus laevis O12977 449 50256 E22 R T S L I T S E S P P L P S Y
Zebra Danio Brachydanio rerio Q90ZE4 441 49151 S20 E R S A L V Q S E S P T V P S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02194 541 59286 P35 A A E R L E R P P R R Q Q Q R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52166 444 50016 T19 G A D A E T H T V Y G T N L I
Sea Urchin Strong. purpuratus XP_001178622 480 53857 N46 P T S D G A S N A R R P I Q V
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SIK7 397 43993
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 68.3 59.9 N.A. 95.7 95.3 N.A. 79.5 74.7 72.6 71.4 N.A. 46.5 N.A. 51.1 58.7
Protein Similarity: 100 99.7 68.3 60.6 N.A. 97 96.6 N.A. 85.2 81.8 82.8 80.1 N.A. 60.4 N.A. 67.1 69.1
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 93.3 6.6 6.6 13.3 N.A. 0 N.A. 6.6 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 6.6 13.3 13.3 N.A. 6.6 N.A. 20 20
Percent
Protein Identity: N.A. N.A. N.A. 23.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 15 0 15 0 8 8 0 8 0 0 50 0 0 0 % A
% Cys: 0 0 50 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 8 50 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 58 0 8 0 58 8 0 15 8 0 0 0 50 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 0 0 8 0 0 0 0 0 8 0 0 0 0 % G
% His: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 0 0 0 0 0 0 8 0 8 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 0 0 15 15 0 0 0 50 0 0 8 0 8 0 % L
% Met: 0 0 0 0 8 0 0 0 0 50 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 0 0 0 8 0 0 % N
% Pro: 8 0 0 0 0 0 0 8 8 15 22 8 15 8 50 % P
% Gln: 0 0 0 0 0 0 8 0 0 0 0 8 8 15 0 % Q
% Arg: 15 8 0 8 0 50 8 0 0 15 15 0 0 0 8 % R
% Ser: 0 0 29 0 0 8 15 58 15 8 50 0 0 65 8 % S
% Thr: 0 22 0 0 0 15 50 8 0 0 0 15 0 0 0 % T
% Val: 0 50 0 0 0 8 0 0 8 0 0 8 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 15 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _