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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
26.02
Human Site:
S7
Identified Species:
44.03
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
S7
_
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Chimpanzee
Pan troglodytes
XP_514247
448
50096
S7
_
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
S213
A
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Dog
Lupus familis
XP_547503
717
78133
S276
A
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
S7
_
M
L
A
F
M
A
S
D
S
E
E
E
V
C
Rat
Rattus norvegicus
O88777
448
50033
S7
_
M
L
T
F
M
A
S
D
S
E
E
E
V
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
S7
_
M
I
T
F
M
N
S
D
S
E
E
E
V
C
Chicken
Gallus gallus
Q90X07
451
50448
E13
N
N
S
D
S
E
D
E
P
C
N
E
R
T
S
Frog
Xenopus laevis
O12977
449
50256
E10
K
L
S
D
S
E
D
E
E
C
N
E
R
T
S
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
E8
M
N
T
S
D
S
E
E
D
S
Y
N
E
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
G23
S
E
D
D
A
N
V
G
S
Q
I
G
A
A
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
Q7
_
M
P
S
T
R
R
Q
Q
E
G
G
G
A
D
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
A34
A
P
T
E
T
M
S
A
E
I
L
A
P
T
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
93.3
93.3
N.A.
92.8
100
N.A.
85.7
6.6
6.6
20
N.A.
0
N.A.
7.1
6.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
92.8
100
N.A.
92.8
6.6
20
26.6
N.A.
0
N.A.
14.2
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
22
0
0
8
8
0
43
8
0
0
0
8
8
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
50
% C
% Asp:
0
0
8
22
8
0
15
0
58
0
0
0
0
0
8
% D
% Glu:
0
8
0
8
0
15
8
22
15
8
50
65
58
0
8
% E
% Phe:
0
0
0
0
50
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
8
15
8
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
0
8
8
0
0
0
0
% I
% Lys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
43
0
0
0
0
0
0
0
8
0
0
0
0
% L
% Met:
8
58
0
0
0
58
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
15
0
0
0
8
8
0
0
0
15
8
0
0
0
% N
% Pro:
0
8
8
0
0
0
0
0
8
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
0
0
8
8
8
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
8
0
0
0
0
0
15
8
0
% R
% Ser:
8
0
15
15
15
8
8
50
8
58
0
0
0
0
29
% S
% Thr:
0
0
15
43
15
0
0
0
0
0
0
0
0
22
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
50
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
43
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _