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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
33.94
Human Site:
T113
Identified Species:
57.44
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
T113
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Chimpanzee
Pan troglodytes
XP_514247
448
50096
T113
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
T319
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Dog
Lupus familis
XP_547503
717
78133
T382
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
T113
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Rat
Rattus norvegicus
O88777
448
50033
T113
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
E113
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Y
Chicken
Gallus gallus
Q90X07
451
50448
T119
I
K
S
V
R
F
Y
T
E
K
N
G
Q
L
I
Frog
Xenopus laevis
O12977
449
50256
T116
I
K
S
V
S
F
Y
T
E
K
D
G
Q
L
I
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
S114
V
S
F
Y
T
E
K
S
G
Q
R
L
I
Y
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
N129
I
N
S
I
S
F
Y
N
S
T
D
V
Y
L
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
V113
L
V
M
L
C
V
V
V
L
M
T
V
L
L
I
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
E140
S
T
V
S
F
Y
T
E
S
G
D
V
Y
L
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
T85
V
V
F
V
A
A
I
T
V
A
T
F
V
L
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
0
100
86.6
0
N.A.
33.3
N.A.
13.3
13.3
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
20
100
93.3
20
N.A.
53.3
N.A.
26.6
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
0
0
0
8
0
0
0
0
0
% A
% Cys:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
22
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
0
15
58
0
0
0
0
0
0
% E
% Phe:
0
0
15
0
15
65
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
8
8
8
58
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
65
0
0
8
0
0
8
0
0
0
0
0
8
8
72
% I
% Lys:
8
58
0
0
0
0
8
0
8
58
0
0
0
0
0
% K
% Leu:
8
0
0
8
0
0
0
0
8
0
0
8
15
86
8
% L
% Met:
0
0
8
0
0
0
0
0
0
8
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
8
0
8
50
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
8
0
8
58
0
0
% Q
% Arg:
0
0
0
8
50
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
8
15
65
8
15
0
0
8
15
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
8
0
15
65
0
8
15
0
0
0
8
% T
% Val:
15
15
15
65
0
8
8
8
8
0
0
22
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
0
15
65
0
0
0
0
0
15
8
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _