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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSEN2 All Species: 32.42
Human Site: T125 Identified Species: 54.87
UniProt: P49810 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.15
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49810 NP_000438.2 448 50140 T125 Q L I Y T P F T E D T P S V G
Chimpanzee Pan troglodytes XP_514247 448 50096 T125 Q L I Y T P F T E D T A S V G
Rhesus Macaque Macaca mulatta XP_001087264 654 71396 T331 Q L I Y T P F T E D T P S V G
Dog Lupus familis XP_547503 717 78133 T394 Q L I Y T P F T E D T P S V G
Cat Felis silvestris
Mouse Mus musculus Q61144 448 49965 T125 Q L I Y T P F T E D T P S V G
Rat Rattus norvegicus O88777 448 50033 T125 Q L I Y T P F T E D T P S V G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514754 455 50711 E125 L I Y T P F T E D T P S V G Q
Chicken Gallus gallus Q90X07 451 50448 S131 Q L I Y T P F S E D T P S V G
Frog Xenopus laevis O12977 449 50256 S128 Q L I Y T P F S E D T T S V G
Zebra Danio Brachydanio rerio Q90ZE4 441 49151 D126 I Y T P F E E D P N S V G Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02194 541 59286 H141 Y L L Y T P F H E Q S P E P S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52166 444 50016 Y125 L L I V F Y K Y K F Y K L I H
Sea Urchin Strong. purpuratus XP_001178622 480 53857 H152 Y L I Y T P F H E K S D Q A G
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SIK7 397 43993 L97 V L V L L F Y L R C V K F L K
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 68.3 59.9 N.A. 95.7 95.3 N.A. 79.5 74.7 72.6 71.4 N.A. 46.5 N.A. 51.1 58.7
Protein Similarity: 100 99.7 68.3 60.6 N.A. 97 96.6 N.A. 85.2 81.8 82.8 80.1 N.A. 60.4 N.A. 67.1 69.1
P-Site Identity: 100 93.3 100 100 N.A. 100 100 N.A. 0 93.3 86.6 0 N.A. 46.6 N.A. 13.3 53.3
P-Site Similarity: 100 93.3 100 100 N.A. 100 100 N.A. 13.3 100 93.3 13.3 N.A. 60 N.A. 26.6 60
Percent
Protein Identity: N.A. N.A. N.A. 23.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 6.6 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 8 0 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 8 8 58 0 8 0 0 0 % D
% Glu: 0 0 0 0 0 8 8 8 72 0 0 0 8 0 0 % E
% Phe: 0 0 0 0 15 15 72 0 0 8 0 0 8 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 8 8 65 % G
% His: 0 0 0 0 0 0 0 15 0 0 0 0 0 0 8 % H
% Ile: 8 8 72 0 0 0 0 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 0 0 0 0 8 0 8 8 0 15 0 0 8 % K
% Leu: 15 86 8 8 8 0 0 8 0 0 0 0 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % N
% Pro: 0 0 0 8 8 72 0 0 8 0 8 50 0 8 0 % P
% Gln: 58 0 0 0 0 0 0 0 0 8 0 0 8 8 8 % Q
% Arg: 0 0 0 0 0 0 0 0 8 0 0 0 0 0 8 % R
% Ser: 0 0 0 0 0 0 0 15 0 0 22 8 58 0 8 % S
% Thr: 0 0 8 8 72 0 8 43 0 8 58 8 0 0 0 % T
% Val: 8 0 8 8 0 0 0 0 0 0 8 8 8 58 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 15 8 8 72 0 8 8 8 0 0 8 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _