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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PSEN2 All Species: 23.33
Human Site: T27 Identified Species: 39.49
UniProt: P49810 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49810 NP_000438.2 448 50140 T27 L M S A E S P T P R S C Q E G
Chimpanzee Pan troglodytes XP_514247 448 50096 T27 L M S A E S P T P R S C Q E G
Rhesus Macaque Macaca mulatta XP_001087264 654 71396 T233 L M S A E S P T P R S C Q E G
Dog Lupus familis XP_547503 717 78133 P296 L M S A E S P P P R C C Q E A
Cat Felis silvestris
Mouse Mus musculus Q61144 448 49965 T27 L M S A E S P T S R S C Q E G
Rat Rattus norvegicus O88777 448 50033 T27 L M S A E S P T S R S C Q D S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001514754 455 50711 T27 L M S A E S P T S R S Y Q D G
Chicken Gallus gallus Q90X07 451 50448 Q33 S P P V P S Y Q D G L Q A S E
Frog Xenopus laevis O12977 449 50256 Q30 S P P L P S Y Q D G V Q A S E
Zebra Danio Brachydanio rerio Q90ZE4 441 49151 Y28 E S P T V P S Y N Q D N A M S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster O02194 541 59286 N43 P R R Q Q Q R N N Y G S S N Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P52166 444 50016 T27 V Y G T N L I T N R N S Q E D
Sea Urchin Strong. purpuratus XP_001178622 480 53857 E54 A R R P I Q V E G S N N P S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9SIK7 397 43993
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 68.3 59.9 N.A. 95.7 95.3 N.A. 79.5 74.7 72.6 71.4 N.A. 46.5 N.A. 51.1 58.7
Protein Similarity: 100 99.7 68.3 60.6 N.A. 97 96.6 N.A. 85.2 81.8 82.8 80.1 N.A. 60.4 N.A. 67.1 69.1
P-Site Identity: 100 100 100 80 N.A. 93.3 80 N.A. 80 6.6 6.6 0 N.A. 0 N.A. 26.6 0
P-Site Similarity: 100 100 100 80 N.A. 93.3 86.6 N.A. 86.6 6.6 6.6 6.6 N.A. 6.6 N.A. 40 6.6
Percent
Protein Identity: N.A. N.A. N.A. 23.4 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 39.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 0 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 0 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 8 0 0 50 0 0 0 0 0 0 0 0 22 0 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 8 43 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 15 0 8 0 0 15 8 % D
% Glu: 8 0 0 0 50 0 0 8 0 0 0 0 0 43 15 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 8 0 0 0 0 0 8 15 8 0 0 0 36 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 8 0 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 50 0 0 8 0 8 0 0 0 0 8 0 0 0 0 % L
% Met: 0 50 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 8 0 0 8 22 0 15 15 0 8 0 % N
% Pro: 8 15 22 8 15 8 50 8 29 0 0 0 8 0 0 % P
% Gln: 0 0 0 8 8 15 0 15 0 8 0 15 58 0 8 % Q
% Arg: 0 15 15 0 0 0 8 0 0 58 0 0 0 0 0 % R
% Ser: 15 8 50 0 0 65 8 0 22 8 43 15 8 22 15 % S
% Thr: 0 0 0 15 0 0 0 50 0 0 0 0 0 0 0 % T
% Val: 8 0 0 8 8 0 8 0 0 0 8 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 15 8 0 8 0 8 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _