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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
10.3
Human Site:
T345
Identified Species:
17.44
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
T345
E
V
F
E
P
P
L
T
G
Y
P
G
E
E
L
Chimpanzee
Pan troglodytes
XP_514247
448
50096
T345
E
V
F
E
P
P
L
T
G
Y
P
G
E
E
L
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
T551
E
V
F
E
P
P
L
T
G
Y
P
G
E
E
L
Dog
Lupus familis
XP_547503
717
78133
P614
E
V
F
E
P
P
L
P
G
Y
P
G
D
E
L
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
P345
E
A
F
E
A
P
L
P
G
Y
P
G
E
E
L
Rat
Rattus norvegicus
O88777
448
50033
P345
E
A
F
E
A
P
Q
P
G
Y
P
G
E
E
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
I344
S
I
P
P
Q
R
G
I
P
A
N
L
P
A
Y
Chicken
Gallus gallus
Q90X07
451
50448
A351
I
L
D
T
R
S
P
A
P
S
H
P
I
T
L
Frog
Xenopus laevis
O12977
449
50256
S348
E
T
R
I
Q
T
Q
S
N
L
S
S
E
D
P
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
A344
A
G
R
R
Q
Y
S
A
E
E
D
L
E
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
G361
P
E
A
A
A
A
S
G
Q
R
T
G
N
S
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
A338
R
V
E
R
E
L
A
A
E
R
P
T
V
Q
D
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
Q372
N
P
W
P
S
H
P
Q
Q
N
N
G
P
S
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
G305
E
T
F
L
E
G
I
G
L
G
S
S
G
A
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
86.6
N.A.
80
66.6
N.A.
0
6.6
13.3
13.3
N.A.
6.6
N.A.
13.3
6.6
P-Site Similarity:
100
100
100
93.3
N.A.
80
66.6
N.A.
6.6
13.3
26.6
13.3
N.A.
6.6
N.A.
20
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
15
8
8
22
8
8
22
0
8
0
0
0
15
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
8
0
0
0
0
0
0
0
8
0
8
8
15
% D
% Glu:
58
8
8
43
15
0
0
0
15
8
0
0
50
50
0
% E
% Phe:
0
0
50
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
8
15
43
8
0
58
8
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
8
0
0
0
8
% H
% Ile:
8
8
0
8
0
0
8
8
0
0
0
0
8
0
8
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
8
0
8
36
0
8
8
0
15
0
0
43
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
8
8
15
0
8
0
8
% N
% Pro:
8
8
8
15
29
43
15
22
15
0
50
8
15
0
15
% P
% Gln:
0
0
0
0
22
0
15
8
15
0
0
0
0
8
0
% Q
% Arg:
8
0
15
15
8
8
0
0
0
15
0
0
0
0
0
% R
% Ser:
8
0
0
0
8
8
15
8
0
8
15
15
0
15
0
% S
% Thr:
0
15
0
8
0
8
0
22
0
0
8
8
0
8
0
% T
% Val:
0
36
0
0
0
0
0
0
0
0
0
0
8
0
0
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
0
0
43
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _