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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PSEN2
All Species:
48.79
Human Site:
Y294
Identified Species:
82.56
UniProt:
P49810
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49810
NP_000438.2
448
50140
Y294
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Chimpanzee
Pan troglodytes
XP_514247
448
50096
Y294
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Rhesus Macaque
Macaca mulatta
XP_001087264
654
71396
Y500
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Dog
Lupus familis
XP_547503
717
78133
Y563
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Cat
Felis silvestris
Mouse
Mus musculus
Q61144
448
49965
Y294
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Rat
Rattus norvegicus
O88777
448
50033
Y294
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514754
455
50711
Y293
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
P
Chicken
Gallus gallus
Q90X07
451
50448
Y300
P
I
F
P
A
L
I
Y
S
S
A
M
I
W
T
Frog
Xenopus laevis
O12977
449
50256
Y297
P
I
F
P
A
L
I
Y
S
S
A
M
M
W
T
Zebra Danio
Brachydanio rerio
Q90ZE4
441
49151
Y293
P
I
F
P
A
L
I
Y
S
S
A
M
V
W
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O02194
541
59286
Y310
Q
I
F
P
A
L
I
Y
S
S
T
V
V
Y
A
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P52166
444
50016
T287
P
T
S
S
D
S
N
T
S
T
A
F
P
G
E
Sea Urchin
Strong. purpuratus
XP_001178622
480
53857
Y321
Q
I
F
P
A
L
I
Y
S
S
T
M
V
W
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9SIK7
397
43993
N254
R
E
Q
R
S
S
Q
N
N
A
N
R
N
E
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
68.3
59.9
N.A.
95.7
95.3
N.A.
79.5
74.7
72.6
71.4
N.A.
46.5
N.A.
51.1
58.7
Protein Similarity:
100
99.7
68.3
60.6
N.A.
97
96.6
N.A.
85.2
81.8
82.8
80.1
N.A.
60.4
N.A.
67.1
69.1
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
93.3
93.3
93.3
93.3
N.A.
66.6
N.A.
20
80
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
93.3
100
100
93.3
N.A.
80
N.A.
26.6
80
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.4
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.2
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
86
0
0
0
0
8
79
0
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
0
0
0
0
0
0
8
8
% E
% Phe:
0
0
86
0
0
0
0
0
0
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
86
0
0
0
0
86
0
0
0
0
0
8
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
86
0
0
0
0
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
79
8
0
8
% M
% Asn:
0
0
0
0
0
0
8
8
8
0
8
0
8
0
0
% N
% Pro:
79
0
0
86
0
0
0
0
0
0
0
0
8
0
8
% P
% Gln:
15
0
8
0
0
0
8
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
8
8
8
15
0
0
93
86
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
0
8
0
8
15
0
0
0
58
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
8
72
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
79
0
% W
% Tyr:
0
0
0
0
0
0
0
86
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _