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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TSC2 All Species: 24.24
Human Site: T996 Identified Species: 53.33
UniProt: P49815 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.2
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49815 NP_000539.2 1807 200608 T996 S R I Q T S L T S A S L G S A
Chimpanzee Pan troglodytes XP_523477 1803 200189 T996 S R I Q T S L T S A S L G S A
Rhesus Macaque Macaca mulatta XP_001083256 1807 200600 T996 S R I Q T S L T S A S L G S A
Dog Lupus familis XP_852047 1813 201226 T996 S R I Q T S L T S A S L G S A
Cat Felis silvestris
Mouse Mus musculus Q61037 1814 202053 T996 S R I Q T S L T S A S L G S A
Rat Rattus norvegicus P49816 1809 201259 T996 S R I Q T S L T S A S L G S A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516748 947 107028 L172 L Q W M S V G L S S D F L L V
Chicken Gallus gallus
Frog Xenopus laevis
Zebra Danio Brachydanio rerio XP_695912 1128 123244 K353 M Q A D D A L K T V H L E L T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524177 1847 204101 A1067 H S S G N E S A G S T E L T S
Honey Bee Apis mellifera XP_395739 1813 206229 S999 L M A R Y T F S T Y S A R P K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_786931 1947 217345 R1096 E D G S H S A R A G S K V M F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.8 97.9 91.2 N.A. 88.9 91 N.A. 44.1 N.A. N.A. 35.8 N.A. 29.8 38.2 N.A. 31.1
Protein Similarity: 100 99 99 94.6 N.A. 92.2 93.9 N.A. 48.3 N.A. N.A. 44.3 N.A. 49.7 58.6 N.A. 48.9
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 6.6 N.A. N.A. 13.3 N.A. 0 6.6 N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 26.6 N.A. N.A. 33.3 N.A. 26.6 33.3 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 19 0 0 10 10 10 10 55 0 10 0 0 55 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 10 10 0 0 0 0 0 10 0 0 0 0 % D
% Glu: 10 0 0 0 0 10 0 0 0 0 0 10 10 0 0 % E
% Phe: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 10 % F
% Gly: 0 0 10 10 0 0 10 0 10 10 0 0 55 0 0 % G
% His: 10 0 0 0 10 0 0 0 0 0 10 0 0 0 0 % H
% Ile: 0 0 55 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 10 0 0 0 10 0 0 10 % K
% Leu: 19 0 0 0 0 0 64 10 0 0 0 64 19 19 0 % L
% Met: 10 10 0 10 0 0 0 0 0 0 0 0 0 10 0 % M
% Asn: 0 0 0 0 10 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % P
% Gln: 0 19 0 55 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 55 0 10 0 0 0 10 0 0 0 0 10 0 0 % R
% Ser: 55 10 10 10 10 64 10 10 64 19 73 0 0 55 10 % S
% Thr: 0 0 0 0 55 10 0 55 19 0 10 0 0 10 10 % T
% Val: 0 0 0 0 0 10 0 0 0 10 0 0 10 0 10 % V
% Trp: 0 0 10 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 0 0 10 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _