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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3A
All Species:
26.67
Human Site:
S431
Identified Species:
41.9
UniProt:
P49840
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49840
NP_063937.2
483
50981
S431
N
F
S
A
G
E
L
S
I
Q
P
S
L
N
A
Chimpanzee
Pan troglodytes
XP_530044
483
51007
S431
N
F
S
A
G
E
L
S
I
Q
P
S
L
N
A
Rhesus Macaque
Macaca mulatta
XP_001104964
483
50993
S431
N
F
S
A
G
E
L
S
I
Q
P
S
L
N
A
Dog
Lupus familis
XP_852706
441
48143
S389
N
F
S
P
G
E
L
S
I
Q
P
S
L
N
A
Cat
Felis silvestris
Mouse
Mus musculus
Q2NL51
490
51642
S432
N
F
S
P
G
E
L
S
I
Q
P
S
L
N
A
Rat
Rattus norvegicus
P18265
483
51008
S431
N
F
S
P
G
E
L
S
I
Q
P
S
L
N
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
S382
F
T
T
Q
E
L
S
S
N
P
S
L
A
S
I
Frog
Xenopus laevis
NP_001083752
420
46885
S368
N
F
T
T
Q
E
L
S
S
N
P
S
L
S
S
Zebra Danio
Brachydanio rerio
NP_001038386
462
50821
P411
L
P
S
G
R
E
L
P
P
L
F
N
F
T
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
L919
F
N
F
T
E
H
E
L
S
I
Q
P
S
L
V
Honey Bee
Apis mellifera
XP_392504
434
48445
N383
L
R
I
Q
P
S
L
N
S
I
L
K
P
K
Y
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
P311
T
P
T
S
R
P
T
P
Q
A
A
C
Q
H
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
R243
D
F
K
T
A
F
P
R
W
Q
A
Q
D
L
A
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
F357
M
E
A
I
V
H
P
F
F
D
E
L
R
D
P
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
S319
N
A
L
Q
C
L
C
S
P
Y
F
D
E
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.7
85.5
N.A.
93.8
97
N.A.
N.A.
67.9
67.4
71.8
N.A.
33.4
64.1
55.2
N.A.
Protein Similarity:
100
99.7
99.7
86.3
N.A.
95.5
97.7
N.A.
N.A.
74.9
74.5
77.6
N.A.
38
75.1
63.7
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
6.6
53.3
20
N.A.
0
6.6
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
20
73.3
26.6
N.A.
0
13.3
26.6
N.A.
Percent
Protein Identity:
N.A.
24.4
N.A.
52.8
40.7
N.A.
Protein Similarity:
N.A.
38.1
N.A.
63.7
55.4
N.A.
P-Site Identity:
N.A.
20
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
7
20
7
0
0
0
0
7
14
0
7
0
54
% A
% Cys:
0
0
0
0
7
0
7
0
0
0
0
7
0
0
0
% C
% Asp:
7
0
0
0
0
0
0
0
0
7
0
7
7
7
0
% D
% Glu:
0
7
0
0
14
54
7
0
0
0
7
0
7
0
0
% E
% Phe:
14
54
7
0
0
7
0
7
7
0
14
0
7
0
0
% F
% Gly:
0
0
0
7
40
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
14
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
0
7
7
0
0
0
0
40
14
0
0
0
0
7
% I
% Lys:
0
0
7
0
0
0
0
0
0
0
0
7
0
7
7
% K
% Leu:
14
0
7
0
0
14
60
7
0
7
7
14
47
20
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
54
7
0
0
0
0
0
7
7
7
0
7
0
40
0
% N
% Pro:
0
14
0
20
7
7
14
14
14
7
47
7
7
0
7
% P
% Gln:
0
0
0
20
7
0
0
0
7
47
7
7
7
0
0
% Q
% Arg:
0
7
0
0
14
0
0
7
0
0
0
0
7
0
0
% R
% Ser:
0
0
47
7
0
7
7
60
20
0
7
47
7
14
7
% S
% Thr:
7
7
20
20
0
0
7
0
0
0
0
0
0
7
7
% T
% Val:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
7
% V
% Trp:
0
0
0
0
0
0
0
0
7
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _