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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3A
All Species:
20.3
Human Site:
S458
Identified Species:
31.9
UniProt:
P49840
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49840
NP_063937.2
483
50981
S458
T
T
T
L
T
P
S
S
Q
A
L
T
E
T
P
Chimpanzee
Pan troglodytes
XP_530044
483
51007
S458
T
T
T
L
T
Q
S
S
Q
A
L
T
E
T
P
Rhesus Macaque
Macaca mulatta
XP_001104964
483
50993
S458
T
T
T
L
T
Q
S
S
Q
A
L
T
E
T
P
Dog
Lupus familis
XP_852706
441
48143
S416
T
A
S
L
T
P
S
S
Q
A
L
S
E
A
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q2NL51
490
51642
S459
P
A
S
P
L
T
T
S
Y
N
P
S
S
Q
A
Rat
Rattus norvegicus
P18265
483
51008
S458
P
A
T
L
T
S
S
S
Q
A
L
T
E
T
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
A409
S
T
P
T
N
A
T
A
A
S
D
V
N
A
G
Frog
Xenopus laevis
NP_001083752
420
46885
T395
V
S
T
T
S
N
T
T
S
T
S
D
S
N
T
Zebra Danio
Brachydanio rerio
NP_001038386
462
50821
A438
L
I
P
P
H
A
R
A
Q
T
V
A
S
S
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
S946
G
P
G
G
N
R
P
S
A
G
G
A
A
S
I
Honey Bee
Apis mellifera
XP_392504
434
48445
N410
P
V
A
G
S
S
G
N
V
S
D
N
N
V
N
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
T338
P
S
G
R
P
L
P
T
L
E
M
D
G
P
M
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y270
L
L
S
K
M
L
R
Y
E
P
S
K
R
I
T
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
E384
L
F
N
F
K
P
Q
E
L
K
G
A
S
L
E
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
E346
L
K
L
L
E
F
D
E
N
V
E
L
G
H
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
99.7
85.5
N.A.
93.8
97
N.A.
N.A.
67.9
67.4
71.8
N.A.
33.4
64.1
55.2
N.A.
Protein Similarity:
100
99.7
99.7
86.3
N.A.
95.5
97.7
N.A.
N.A.
74.9
74.5
77.6
N.A.
38
75.1
63.7
N.A.
P-Site Identity:
100
93.3
93.3
66.6
N.A.
6.6
73.3
N.A.
N.A.
6.6
6.6
6.6
N.A.
6.6
0
0
N.A.
P-Site Similarity:
100
93.3
93.3
80
N.A.
26.6
73.3
N.A.
N.A.
33.3
33.3
26.6
N.A.
13.3
20
20
N.A.
Percent
Protein Identity:
N.A.
24.4
N.A.
52.8
40.7
N.A.
Protein Similarity:
N.A.
38.1
N.A.
63.7
55.4
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
6.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
20
7
0
0
14
0
14
14
34
0
20
7
14
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
7
0
0
0
14
14
0
0
0
% D
% Glu:
0
0
0
0
7
0
0
14
7
7
7
0
34
0
7
% E
% Phe:
0
7
0
7
0
7
0
0
0
0
0
0
0
0
0
% F
% Gly:
7
0
14
14
0
0
7
0
0
7
14
0
14
0
7
% G
% His:
0
0
0
0
7
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
0
7
0
0
0
0
0
0
0
0
0
0
0
7
7
% I
% Lys:
0
7
0
7
7
0
0
0
0
7
0
7
0
0
0
% K
% Leu:
27
7
7
40
7
14
0
0
14
0
34
7
0
7
7
% L
% Met:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
7
% M
% Asn:
0
0
7
0
14
7
0
7
7
7
0
7
14
7
14
% N
% Pro:
27
7
14
14
7
20
14
0
0
7
7
0
0
7
20
% P
% Gln:
0
0
0
0
0
14
7
0
40
0
0
0
0
7
14
% Q
% Arg:
0
0
0
7
0
7
14
0
0
0
0
0
7
0
0
% R
% Ser:
7
14
20
0
14
14
34
47
7
14
14
14
27
14
0
% S
% Thr:
27
27
34
14
34
7
20
14
0
14
0
27
0
27
14
% T
% Val:
7
7
0
0
0
0
0
0
7
7
7
7
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
7
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _