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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3B
All Species:
30
Human Site:
S398
Identified Species:
50.77
UniProt:
P49841
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49841
NP_001139628.1
420
46744
S398
P
T
N
A
T
A
A
S
D
A
N
T
G
D
R
Chimpanzee
Pan troglodytes
XP_001164371
420
46753
S398
P
T
N
A
T
A
A
S
D
A
N
T
G
D
R
Rhesus Macaque
Macaca mulatta
XP_001110547
420
46919
Q398
N
L
P
A
L
A
S
Q
N
A
N
T
G
D
R
Dog
Lupus familis
XP_856611
420
46696
S398
P
T
N
A
T
A
A
S
D
A
N
A
G
D
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV60
420
46692
S398
P
A
N
A
T
A
A
S
D
T
N
A
G
D
R
Rat
Rattus norvegicus
P18266
420
46724
S398
P
A
N
A
T
A
A
S
D
T
N
A
G
D
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
S411
P
T
N
A
T
A
A
S
D
V
N
A
G
E
R
Frog
Xenopus laevis
NP_001083752
420
46885
S398
T
S
N
T
T
S
T
S
D
S
N
T
G
E
R
Zebra Danio
Brachydanio rerio
NP_571456
421
46854
S398
P
T
N
P
S
A
T
S
D
A
N
S
G
D
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
A950
N
R
P
S
A
G
G
A
A
S
I
A
A
S
G
Honey Bee
Apis mellifera
XP_392504
434
48445
S407
Q
S
E
P
V
A
G
S
S
G
N
V
S
D
N
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
M341
R
P
L
P
T
L
E
M
D
G
P
M
G
T
G
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
S389
P
Q
E
L
K
G
A
S
L
E
L
L
S
K
L
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
E349
L
E
F
D
E
N
V
E
L
G
H
L
S
P
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94.7
99.7
N.A.
99
98.8
N.A.
N.A.
93.7
93.3
95
N.A.
31.8
70.9
64.7
N.A.
Protein Similarity:
100
98.8
96.4
99.7
N.A.
99
99
N.A.
N.A.
95.1
97.1
97.1
N.A.
34.9
80.4
74.2
N.A.
P-Site Identity:
100
100
53.3
93.3
N.A.
80
80
N.A.
N.A.
80
53.3
73.3
N.A.
0
26.6
20
N.A.
P-Site Similarity:
100
100
66.6
93.3
N.A.
80
80
N.A.
N.A.
86.6
80
86.6
N.A.
20
33.3
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60.2
44.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
15
0
50
8
65
50
8
8
36
0
36
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
65
0
0
0
0
58
8
% D
% Glu:
0
8
15
0
8
0
8
8
0
8
0
0
0
15
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
15
15
0
0
22
0
0
72
0
15
% G
% His:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% K
% Leu:
8
8
8
8
8
8
0
0
15
0
8
15
0
0
8
% L
% Met:
0
0
0
0
0
0
0
8
0
0
0
8
0
0
0
% M
% Asn:
15
0
58
0
0
8
0
0
8
0
72
0
0
0
8
% N
% Pro:
58
8
15
22
0
0
0
0
0
0
8
0
0
8
0
% P
% Gln:
8
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% Q
% Arg:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
65
% R
% Ser:
0
15
0
8
8
8
8
72
8
15
0
8
22
8
0
% S
% Thr:
8
36
0
8
58
0
15
0
0
15
0
29
0
8
0
% T
% Val:
0
0
0
0
8
0
8
0
0
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _