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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GSK3B All Species: 22.12
Human Site: T390 Identified Species: 37.44
UniProt: P49841 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49841 NP_001139628.1 420 46744 T390 R I Q A A A S T P T N A T A A
Chimpanzee Pan troglodytes XP_001164371 420 46753 T390 R I Q A A A S T P T N A T A A
Rhesus Macaque Macaca mulatta XP_001110547 420 46919 S390 G L E L L A S S N L P A L A S
Dog Lupus familis XP_856611 420 46696 T390 R I Q A A A S T P T N A T A A
Cat Felis silvestris
Mouse Mus musculus Q9WV60 420 46692 P390 R I Q A A A S P P A N A T A A
Rat Rattus norvegicus P18266 420 46724 P390 R I Q A A A S P P A N A T A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_416557 433 48108 T403 R N Q A A A S T P T N A T A A
Frog Xenopus laevis NP_001083752 420 46885 T390 R N Q A A V S T T S N T T S T
Zebra Danio Brachydanio rerio NP_571456 421 46854 T390 R N Q A G A S T P T N P S A T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P18431 1067 114422 G942 Q N A S G P G G N R P S A G G
Honey Bee Apis mellifera XP_392504 434 48445 G399 Q T S E N A G G Q S E P V A G
Nematode Worm Caenorhab. elegans Q9U2Q9 362 40864 G333 P D A R L P S G R P L P T L E
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q8VZD5 410 46056 K381 L P P L F N F K P Q E L K G A
Baker's Yeast Sacchar. cerevisiae P38615 370 42986 L341 Q I T T D L K L L E F D E N V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98 94.7 99.7 N.A. 99 98.8 N.A. N.A. 93.7 93.3 95 N.A. 31.8 70.9 64.7 N.A.
Protein Similarity: 100 98.8 96.4 99.7 N.A. 99 99 N.A. N.A. 95.1 97.1 97.1 N.A. 34.9 80.4 74.2 N.A.
P-Site Identity: 100 100 26.6 100 N.A. 86.6 86.6 N.A. N.A. 93.3 53.3 66.6 N.A. 0 13.3 13.3 N.A.
P-Site Similarity: 100 100 53.3 100 N.A. 86.6 86.6 N.A. N.A. 93.3 66.6 73.3 N.A. 20 26.6 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 60.2 44.7 N.A.
Protein Similarity: N.A. N.A. N.A. 74 63.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 15 58 50 65 0 0 0 15 0 50 8 65 50 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 0 0 8 0 0 0 0 0 0 8 0 0 0 % D
% Glu: 0 0 8 8 0 0 0 0 0 8 15 0 8 0 8 % E
% Phe: 0 0 0 0 8 0 8 0 0 0 8 0 0 0 0 % F
% Gly: 8 0 0 0 15 0 15 22 0 0 0 0 0 15 15 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 43 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 8 8 0 0 0 0 8 0 0 % K
% Leu: 8 8 0 15 15 8 0 8 8 8 8 8 8 8 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 29 0 0 8 8 0 0 15 0 58 0 0 8 0 % N
% Pro: 8 8 8 0 0 15 0 15 58 8 15 22 0 0 0 % P
% Gln: 22 0 58 0 0 0 0 0 8 8 0 0 0 0 0 % Q
% Arg: 58 0 0 8 0 0 0 0 8 8 0 0 0 0 0 % R
% Ser: 0 0 8 8 0 0 72 8 0 15 0 8 8 8 8 % S
% Thr: 0 8 8 8 0 0 0 43 8 36 0 8 58 0 15 % T
% Val: 0 0 0 0 0 8 0 0 0 0 0 0 8 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _