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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3B
All Species:
36.67
Human Site:
T408
Identified Species:
62.05
UniProt:
P49841
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49841
NP_001139628.1
420
46744
T408
N
T
G
D
R
G
Q
T
N
N
A
A
S
A
S
Chimpanzee
Pan troglodytes
XP_001164371
420
46753
T408
N
T
G
D
R
G
Q
T
N
N
A
A
S
A
S
Rhesus Macaque
Macaca mulatta
XP_001110547
420
46919
T408
N
T
G
D
R
G
Q
T
N
N
A
A
S
A
S
Dog
Lupus familis
XP_856611
420
46696
T408
N
A
G
D
R
G
Q
T
N
N
A
A
S
A
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV60
420
46692
T408
N
A
G
D
R
G
Q
T
N
N
A
A
S
A
S
Rat
Rattus norvegicus
P18266
420
46724
T408
N
A
G
D
R
G
Q
T
N
N
A
A
S
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
T421
N
A
G
E
R
V
Q
T
N
S
V
A
T
A
S
Frog
Xenopus laevis
NP_001083752
420
46885
T408
N
T
G
E
R
G
S
T
N
N
A
A
S
A
S
Zebra Danio
Brachydanio rerio
NP_571456
421
46854
T408
N
S
G
D
R
S
Q
T
T
T
A
A
S
A
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
S960
I
A
A
S
G
S
T
S
V
S
S
T
G
S
G
Honey Bee
Apis mellifera
XP_392504
434
48445
N417
N
V
S
D
N
N
V
N
A
T
L
S
T
S
K
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
S351
P
M
G
T
G
E
V
S
T
T
S
G
D
V
A
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
D399
L
L
S
K
L
I
P
D
H
A
R
K
Q
C
S
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
S359
H
L
S
P
D
E
L
S
S
V
K
K
K
L
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94.7
99.7
N.A.
99
98.8
N.A.
N.A.
93.7
93.3
95
N.A.
31.8
70.9
64.7
N.A.
Protein Similarity:
100
98.8
96.4
99.7
N.A.
99
99
N.A.
N.A.
95.1
97.1
97.1
N.A.
34.9
80.4
74.2
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
60
86.6
73.3
N.A.
0
13.3
6.6
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
N.A.
80
93.3
80
N.A.
26.6
33.3
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60.2
44.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
36
8
0
0
0
0
0
8
8
58
65
0
65
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
58
8
0
0
8
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
15
0
15
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
72
0
15
50
0
0
0
0
0
8
8
0
8
% G
% His:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
0
0
0
0
0
8
15
8
0
8
% K
% Leu:
8
15
0
0
8
0
8
0
0
0
8
0
0
8
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
72
0
0
0
8
8
0
8
58
50
0
0
0
0
0
% N
% Pro:
8
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
58
0
0
0
0
0
8
0
0
% Q
% Arg:
0
0
0
0
65
0
0
0
0
0
8
0
0
0
0
% R
% Ser:
0
8
22
8
0
15
8
22
8
15
15
8
58
15
72
% S
% Thr:
0
29
0
8
0
0
8
65
15
22
0
8
15
0
0
% T
% Val:
0
8
0
0
0
8
15
0
8
8
8
0
0
8
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _