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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GSK3B
All Species:
40.91
Human Site:
Y127
Identified Species:
69.23
UniProt:
P49841
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49841
NP_001139628.1
420
46744
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Chimpanzee
Pan troglodytes
XP_001164371
420
46753
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Rhesus Macaque
Macaca mulatta
XP_001110547
420
46919
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Dog
Lupus familis
XP_856611
420
46696
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q9WV60
420
46692
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Rat
Rattus norvegicus
P18266
420
46724
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_416557
433
48108
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Frog
Xenopus laevis
NP_001083752
420
46885
Y127
G
E
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Zebra Danio
Brachydanio rerio
NP_571456
421
46854
Y127
G
D
K
K
D
E
V
Y
L
N
L
V
L
D
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P18431
1067
114422
F678
G
E
K
R
D
E
V
F
L
N
L
V
L
E
Y
Honey Bee
Apis mellifera
XP_392504
434
48445
Y136
G
D
K
K
D
E
V
Y
L
N
L
V
L
E
Y
Nematode Worm
Caenorhab. elegans
Q9U2Q9
362
40864
M81
K
N
R
E
L
Q
I
M
R
K
L
N
H
P
N
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q8VZD5
410
46056
N126
M
R
L
L
D
H
P
N
V
V
S
L
K
H
C
Baker's Yeast
Sacchar. cerevisiae
P38615
370
42986
H89
E
I
M
K
M
L
S
H
I
N
I
I
D
L
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98
94.7
99.7
N.A.
99
98.8
N.A.
N.A.
93.7
93.3
95
N.A.
31.8
70.9
64.7
N.A.
Protein Similarity:
100
98.8
96.4
99.7
N.A.
99
99
N.A.
N.A.
95.1
97.1
97.1
N.A.
34.9
80.4
74.2
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
93.3
N.A.
80
86.6
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
N.A.
100
100
100
N.A.
100
100
33.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
60.2
44.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
74
63.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% C
% Asp:
0
15
0
0
86
0
0
0
0
0
0
0
8
65
0
% D
% Glu:
8
65
0
8
0
79
0
0
0
0
0
0
0
15
0
% E
% Phe:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% F
% Gly:
79
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
8
0
0
0
0
8
8
0
% H
% Ile:
0
8
0
0
0
0
8
0
8
0
8
8
0
0
0
% I
% Lys:
8
0
79
79
0
0
0
0
0
8
0
0
8
0
8
% K
% Leu:
0
0
8
8
8
8
0
0
79
0
86
8
79
8
0
% L
% Met:
8
0
8
0
8
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
0
0
0
8
0
86
0
8
0
0
8
% N
% Pro:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% P
% Gln:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
8
8
0
0
0
0
8
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
79
0
8
8
0
79
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
72
0
0
0
0
0
0
79
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _