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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GZMK
All Species:
17.88
Human Site:
S209
Identified Species:
43.7
UniProt:
P49863
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49863
NP_002095.1
264
28882
S209
D
A
K
G
Q
K
D
S
C
K
G
D
S
G
G
Chimpanzee
Pan troglodytes
XP_527196
264
28878
S209
D
A
K
G
Q
K
D
S
C
K
G
D
S
G
G
Rhesus Macaque
Macaca mulatta
XP_001097338
264
28962
S209
D
A
K
G
Q
K
D
S
C
K
G
D
S
G
G
Dog
Lupus familis
XP_546318
268
29903
S209
D
T
R
G
Q
K
D
S
C
Q
G
D
S
G
G
Cat
Felis silvestris
Mouse
Mus musculus
O35205
263
29232
S208
D
A
R
G
Q
K
D
S
C
K
G
D
S
G
G
Rat
Rattus norvegicus
P49864
258
28446
C204
R
R
G
E
K
D
S
C
K
G
D
S
G
G
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517361
237
25958
D183
C
T
E
S
R
K
K
D
T
C
K
G
D
S
G
Chicken
Gallus gallus
Q90627
248
26051
G193
I
C
I
G
Y
L
N
G
G
K
D
S
C
Q
G
Frog
Xenopus laevis
Q63ZK0
263
29212
D208
K
K
D
S
C
E
G
D
S
G
G
P
L
V
C
Zebra Danio
Brachydanio rerio
XP_001335076
257
28823
D203
H
R
G
T
C
W
G
D
S
G
G
P
L
E
C
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
93.5
71.2
N.A.
72.3
70.8
N.A.
37.8
38.2
40.9
39
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
100
95
82
N.A.
83.3
83.3
N.A.
55.6
54.9
59.4
56
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
80
N.A.
93.3
6.6
N.A.
13.3
20
6.6
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
100
13.3
N.A.
26.6
26.6
13.3
6.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
40
0
0
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
10
10
0
0
20
0
0
10
50
10
0
0
10
0
20
% C
% Asp:
50
0
10
0
0
10
50
30
0
0
20
50
10
0
0
% D
% Glu:
0
0
10
10
0
10
0
0
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
20
60
0
0
20
10
10
30
70
10
10
60
70
% G
% His:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
10
10
30
0
10
60
10
0
10
50
10
0
0
0
0
% K
% Leu:
0
0
0
0
0
10
0
0
0
0
0
0
20
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
20
0
0
10
% P
% Gln:
0
0
0
0
50
0
0
0
0
10
0
0
0
10
0
% Q
% Arg:
10
20
20
0
10
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
20
0
0
10
50
20
0
0
20
50
10
0
% S
% Thr:
0
20
0
10
0
0
0
0
10
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _