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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFS All Species: 23.03
Human Site: S49 Identified Species: 42.22
UniProt: P49914 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49914 NP_006432.1 203 23256 S49 A H S E Y Q K S K R I S I F L
Chimpanzee Pan troglodytes XP_001154891 203 23207 S49 A H S E Y Q K S K R I S I F L
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852666 203 23320 S50 A H S Q Y Q K S K R I S I F L
Cat Felis silvestris
Mouse Mus musculus Q9D110 203 23183 S49 A H N Q Y Q N S K R I S I F L
Rat Rattus norvegicus NP_001009349 203 23222 S49 A H S Q Y Q N S K R I S I F L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516124 97 11478
Chicken Gallus gallus XP_413857 210 23450 S58 G H S K Y Q E S K R I A I F L
Frog Xenopus laevis NP_001089249 205 23364 A52 Y Q E A Q R V A V F L N M S D
Zebra Danio Brachydanio rerio XP_002662791 199 22883 A51 Y L S S Q R V A V F L N M H D
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097432 201 22863 A49 Q S E I F R Q A Q R V S I Y L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XWE6 206 23542 S51 F Q E S K R L S V Y V S T S G
Sea Urchin Strong. purpuratus XP_001183516 161 18411 K37 R K M F S Q N K L C Y V P Q Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40099 211 24040 L66 T G E I I K N L F Q D G Q E V
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 N.A. 86.2 N.A. 83.2 83.2 N.A. 35.4 66.6 55.6 60 N.A. 35.9 N.A. 37.8 42.3
Protein Similarity: 100 100 N.A. 94.5 N.A. 92.6 93 N.A. 43.3 80.9 80.4 80.3 N.A. 59.1 N.A. 55.8 59.1
P-Site Identity: 100 100 N.A. 93.3 N.A. 80 86.6 N.A. 0 73.3 0 6.6 N.A. 26.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 N.A. 100 N.A. 93.3 93.3 N.A. 0 93.3 33.3 40 N.A. 73.3 N.A. 26.6 6.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 51.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 39 0 0 8 0 0 0 24 0 0 0 8 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 8 0 0 0 16 % D
% Glu: 0 0 31 16 0 0 8 0 0 0 0 0 0 8 0 % E
% Phe: 8 0 0 8 8 0 0 0 8 16 0 0 0 47 0 % F
% Gly: 8 8 0 0 0 0 0 0 0 0 0 8 0 0 8 % G
% His: 0 47 0 0 0 0 0 0 0 0 0 0 0 8 0 % H
% Ile: 0 0 0 16 8 0 0 0 0 0 47 0 54 0 0 % I
% Lys: 0 8 0 8 8 8 24 8 47 0 0 0 0 0 0 % K
% Leu: 0 8 0 0 0 0 8 8 8 0 16 0 0 0 54 % L
% Met: 0 0 8 0 0 0 0 0 0 0 0 0 16 0 0 % M
% Asn: 0 0 8 0 0 0 31 0 0 0 0 16 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % P
% Gln: 8 16 0 24 16 54 8 0 8 8 0 0 8 8 0 % Q
% Arg: 8 0 0 0 0 31 0 0 0 54 0 0 0 0 0 % R
% Ser: 0 8 47 16 8 0 0 54 0 0 0 54 0 16 0 % S
% Thr: 8 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % T
% Val: 0 0 0 0 0 0 16 0 24 0 16 8 0 0 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 16 0 0 0 47 0 0 0 0 8 8 0 0 8 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _