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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MTHFS All Species: 24.85
Human Site: Y156 Identified Species: 45.56
UniProt: P49914 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49914 NP_006432.1 203 23256 Y156 G K G Y Y D A Y L K R C L Q H
Chimpanzee Pan troglodytes XP_001154891 203 23207 Y156 G K G Y Y D A Y L K R C L Q H
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_852666 203 23320 Y157 G R G Y Y D A Y L R R C L Q Q
Cat Felis silvestris
Mouse Mus musculus Q9D110 203 23183 Y156 G K G Y Y D T Y L K R C V Q H
Rat Rattus norvegicus NP_001009349 203 23222 Y156 G K G Y Y D T Y L K R C V Q H
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001516124 97 11478 M63 F Q S N H M D M V K L V S F E
Chicken Gallus gallus XP_413857 210 23450 Y166 G K G Y Y D T Y L G R C M K H
Frog Xenopus laevis NP_001089249 205 23364 F155 G K G Y Y D T F L E R Y M K Q
Zebra Danio Brachydanio rerio XP_002662791 199 22883 Y155 G K G F Y D T Y L E R C R T H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_001097432 201 22863 F155 G M G Y Y D K F L K Q H A E K
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9XWE6 206 23542 F154 G K G Y Y D R F F S T H H K H
Sea Urchin Strong. purpuratus XP_001183516 161 18411 P127 V E E T G V K P V T I A L A F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40099 211 24040 F160 G A G Y Y D D F F Q R Y K I L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.5 N.A. 86.2 N.A. 83.2 83.2 N.A. 35.4 66.6 55.6 60 N.A. 35.9 N.A. 37.8 42.3
Protein Similarity: 100 100 N.A. 94.5 N.A. 92.6 93 N.A. 43.3 80.9 80.4 80.3 N.A. 59.1 N.A. 55.8 59.1
P-Site Identity: 100 100 N.A. 80 N.A. 86.6 86.6 N.A. 6.6 73.3 53.3 66.6 N.A. 46.6 N.A. 46.6 6.6
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 93.3 N.A. 26.6 86.6 80 80 N.A. 66.6 N.A. 60 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 29.3 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 51.1 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 40 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 53.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 0 0 0 0 24 0 0 0 0 8 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 54 0 0 0 % C
% Asp: 0 0 0 0 0 85 16 0 0 0 0 0 0 0 0 % D
% Glu: 0 8 8 0 0 0 0 0 0 16 0 0 0 8 8 % E
% Phe: 8 0 0 8 0 0 0 31 16 0 0 0 0 8 8 % F
% Gly: 85 0 85 0 8 0 0 0 0 8 0 0 0 0 0 % G
% His: 0 0 0 0 8 0 0 0 0 0 0 16 8 0 54 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % I
% Lys: 0 62 0 0 0 0 16 0 0 47 0 0 8 24 8 % K
% Leu: 0 0 0 0 0 0 0 0 70 0 8 0 31 0 8 % L
% Met: 0 8 0 0 0 8 0 8 0 0 0 0 16 0 0 % M
% Asn: 0 0 0 8 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 8 0 0 0 0 0 0 0 % P
% Gln: 0 8 0 0 0 0 0 0 0 8 8 0 0 39 16 % Q
% Arg: 0 8 0 0 0 0 8 0 0 8 70 0 8 0 0 % R
% Ser: 0 0 8 0 0 0 0 0 0 8 0 0 8 0 0 % S
% Thr: 0 0 0 8 0 0 39 0 0 8 8 0 0 8 0 % T
% Val: 8 0 0 0 0 8 0 0 16 0 0 8 16 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 77 85 0 0 54 0 0 0 16 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _