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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MTHFS
All Species:
28.18
Human Site:
Y169
Identified Species:
51.67
UniProt:
P49914
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49914
NP_006432.1
203
23256
Y169
Q
H
Q
E
V
K
P
Y
T
L
A
L
A
F
K
Chimpanzee
Pan troglodytes
XP_001154891
203
23207
Y169
Q
H
Q
E
V
K
P
Y
T
L
A
L
A
F
K
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_852666
203
23320
Y170
Q
Q
Q
D
V
P
P
Y
T
M
A
L
A
F
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9D110
203
23183
Y169
Q
H
Q
E
V
K
P
Y
T
M
A
L
A
F
K
Rat
Rattus norvegicus
NP_001009349
203
23222
Y169
Q
H
Q
K
V
K
P
Y
T
L
A
L
A
F
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516124
97
11478
P76
F
E
E
I
S
S
L
P
K
T
S
W
N
I
L
Chicken
Gallus gallus
XP_413857
210
23450
Y179
K
H
P
S
G
K
P
Y
T
I
A
L
A
F
R
Frog
Xenopus laevis
NP_001089249
205
23364
Y168
K
Q
I
G
A
K
P
Y
T
I
A
L
A
F
Q
Zebra Danio
Brachydanio rerio
XP_002662791
199
22883
Y168
T
H
P
K
G
K
P
Y
T
I
A
L
A
F
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097432
201
22863
I168
E
K
Y
P
H
K
K
I
S
L
M
A
L
S
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9XWE6
206
23542
P167
K
H
F
P
E
N
S
P
K
K
I
G
L
A
L
Sea Urchin
Strong. purpuratus
XP_001183516
161
18411
E140
A
F
K
E
Q
I
C
E
S
I
P
I
T
E
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P40099
211
24040
P173
I
L
H
E
G
Q
K
P
L
L
V
G
L
C
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.5
N.A.
86.2
N.A.
83.2
83.2
N.A.
35.4
66.6
55.6
60
N.A.
35.9
N.A.
37.8
42.3
Protein Similarity:
100
100
N.A.
94.5
N.A.
92.6
93
N.A.
43.3
80.9
80.4
80.3
N.A.
59.1
N.A.
55.8
59.1
P-Site Identity:
100
100
N.A.
66.6
N.A.
93.3
86.6
N.A.
0
60
53.3
66.6
N.A.
13.3
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
86.6
N.A.
100
100
N.A.
13.3
80
73.3
80
N.A.
26.6
N.A.
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
29.3
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
0
0
0
0
0
62
8
62
8
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
8
8
39
8
0
0
8
0
0
0
0
0
8
0
% E
% Phe:
8
8
8
0
0
0
0
0
0
0
0
0
0
62
0
% F
% Gly:
0
0
0
8
24
0
0
0
0
0
0
16
0
0
0
% G
% His:
0
54
8
0
8
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
8
8
0
8
0
8
0
31
8
8
0
8
0
% I
% Lys:
24
8
8
16
0
62
16
0
16
8
0
0
0
0
31
% K
% Leu:
0
8
0
0
0
0
8
0
8
39
0
62
24
0
31
% L
% Met:
0
0
0
0
0
0
0
0
0
16
8
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
0
0
0
0
8
0
8
% N
% Pro:
0
0
16
16
0
8
62
24
0
0
8
0
0
0
0
% P
% Gln:
39
16
39
0
8
8
0
0
0
0
0
0
0
0
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
24
% R
% Ser:
0
0
0
8
8
8
8
0
16
0
8
0
0
8
0
% S
% Thr:
8
0
0
0
0
0
0
0
62
8
0
0
8
0
0
% T
% Val:
0
0
0
0
39
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
62
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _