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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG3 All Species: 17.88
Human Site: S230 Identified Species: 32.78
UniProt: P49916 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49916 NP_002302.2 1009 112907 S230 P R K F S G F S A K P N N S G
Chimpanzee Pan troglodytes XP_511409 922 102716 G211 R K G S A G D G F H G D V Y L
Rhesus Macaque Macaca mulatta XP_001113780 1009 112805 S230 P R K F S G F S A K P N N S G
Dog Lupus familis XP_548265 991 110592 S231 P R K F S G F S A K P N N S G
Cat Felis silvestris
Mouse Mus musculus P97386 1015 113000 S231 P R K F S G F S A A K P N N S
Rat Rattus norvegicus NP_001012011 943 105425 S231 P R K F S G F S A A K P N N S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus NP_001006215 902 101303 N191 V A D K P S Y N V K T Q I I Q
Frog Xenopus laevis NP_001082183 988 110688 G211 S P P S S G T G S S L S T A K
Zebra Danio Brachydanio rerio NP_001025345 752 84159 S41 K I V P N P F S E S A G E M K
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_650187 806 90830 A95 V Y N L Q N K A L I K L F S R
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q27474 773 86292 V62 P D D L T A C V Y M S V N Q L
Sea Urchin Strong. purpuratus XP_786357 875 97201 T164 P S P T P S K T S Y Q G D G S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P04819 755 84810 F44 K Q A T L A R F F T S M K N K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 91.1 97.7 89.4 N.A. 87.3 82.4 N.A. N.A. 71.3 68.2 55.7 N.A. 34.9 N.A. 23.3 48.4
Protein Similarity: 100 91.1 98.8 92.2 N.A. 91.3 86.4 N.A. N.A. 78.9 79.6 64.9 N.A. 48.1 N.A. 39.3 62.9
P-Site Identity: 100 6.6 100 100 N.A. 66.6 66.6 N.A. N.A. 6.6 13.3 13.3 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 26.6 100 100 N.A. 73.3 73.3 N.A. N.A. 20 33.3 20 N.A. 13.3 N.A. 20 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 20.8 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 35.4 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 8 8 0 8 16 0 8 39 16 8 0 0 8 0 % A
% Cys: 0 0 0 0 0 0 8 0 0 0 0 0 0 0 0 % C
% Asp: 0 8 16 0 0 0 8 0 0 0 0 8 8 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % E
% Phe: 0 0 0 39 0 0 47 8 16 0 0 0 8 0 0 % F
% Gly: 0 0 8 0 0 54 0 16 0 0 8 16 0 8 24 % G
% His: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 8 0 0 8 8 0 % I
% Lys: 16 8 39 8 0 0 16 0 0 31 24 0 8 0 24 % K
% Leu: 0 0 0 16 8 0 0 0 8 0 8 8 0 0 16 % L
% Met: 0 0 0 0 0 0 0 0 0 8 0 8 0 8 0 % M
% Asn: 0 0 8 0 8 8 0 8 0 0 0 24 47 24 0 % N
% Pro: 54 8 16 8 16 8 0 0 0 0 24 16 0 0 0 % P
% Gln: 0 8 0 0 8 0 0 0 0 0 8 8 0 8 8 % Q
% Arg: 8 39 0 0 0 0 8 0 0 0 0 0 0 0 8 % R
% Ser: 8 8 0 16 47 16 0 47 16 16 16 8 0 31 24 % S
% Thr: 0 0 0 16 8 0 8 8 0 8 8 0 8 0 0 % T
% Val: 16 0 8 0 0 0 0 8 8 0 0 8 8 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 8 0 0 0 0 8 0 8 8 0 0 0 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _