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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG4 All Species: 35.45
Human Site: S170 Identified Species: 55.71
UniProt: P49917 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49917 NP_001091738.1 911 103971 S170 R K D L I K K S L L Q L I T Q
Chimpanzee Pan troglodytes XP_509726 911 103942 S170 R K D L I K K S L L Q L I T Q
Rhesus Macaque Macaca mulatta XP_001084107 642 73046
Dog Lupus familis XP_542663 911 104163 S170 K K D L I K K S L L Q L I T Q
Cat Felis silvestris
Mouse Mus musculus Q8BTF7 911 104067 S170 K K D L V K K S L L Q L I T Q
Rat Rattus norvegicus NP_001099565 911 104477 S170 R K D L V K K S L L Q L I T Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YB1 912 104431 S175 N K G L V K K S L L Q L I T Q
Frog Xenopus laevis NP_001081114 911 104084 S175 K K E L I E K S L L H L I A N
Zebra Danio Brachydanio rerio NP_001096593 909 103624 S175 Q K D Q V K K S L L H L I T Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572907 918 104813 F168 K Q Q Q L I R F T E Q A S P E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188102 952 108709 S207 K K D L V K Q S L L K L L R K
Poplar Tree Populus trichocarpa XP_002325262 1242 139306 I162 T A V L A A L I N K T N T Q E
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LL84 1219 137833 M162 Q K T N A Q E M K W V I R I I
Baker's Yeast Sacchar. cerevisiae Q08387 944 108496 S170 A S G R G F K S L V K S K P F
Red Bread Mold Neurospora crassa Q7SB49 1046 118891 E218 E Q L P I F E E F Y R Q M N A
Conservation
Percent
Protein Identity: 100 99.4 68.9 91 N.A. 86.9 86.1 N.A. N.A. 76.5 72.5 64.1 N.A. 29.7 N.A. N.A. 48.5
Protein Similarity: 100 99.7 69.8 95.5 N.A. 92.5 92 N.A. N.A. 87.1 84 79.3 N.A. 51.3 N.A. N.A. 65.4
P-Site Identity: 100 100 0 93.3 N.A. 86.6 93.3 N.A. N.A. 80 60 73.3 N.A. 6.6 N.A. N.A. 53.3
P-Site Similarity: 100 100 0 100 N.A. 100 100 N.A. N.A. 86.6 80 86.6 N.A. 40 N.A. N.A. 93.3
Percent
Protein Identity: 27.2 N.A. N.A. 27.6 25.5 29.2
Protein Similarity: 43.3 N.A. N.A. 44.9 46.9 47.2
P-Site Identity: 6.6 N.A. N.A. 6.6 20 6.6
P-Site Similarity: 13.3 N.A. N.A. 33.3 33.3 33.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 7 0 0 14 7 0 0 0 0 0 7 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 47 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 7 0 7 0 0 7 14 7 0 7 0 0 0 0 14 % E
% Phe: 0 0 0 0 0 14 0 7 7 0 0 0 0 0 7 % F
% Gly: 0 0 14 0 7 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % H
% Ile: 0 0 0 0 34 7 0 7 0 0 0 7 54 7 7 % I
% Lys: 34 67 0 0 0 54 60 0 7 7 14 0 7 0 7 % K
% Leu: 0 0 7 60 7 0 7 0 67 60 0 60 7 0 0 % L
% Met: 0 0 0 0 0 0 0 7 0 0 0 0 7 0 0 % M
% Asn: 7 0 0 7 0 0 0 0 7 0 0 7 0 7 7 % N
% Pro: 0 0 0 7 0 0 0 0 0 0 0 0 0 14 0 % P
% Gln: 14 14 7 14 0 7 7 0 0 0 47 7 0 7 47 % Q
% Arg: 20 0 0 7 0 0 7 0 0 0 7 0 7 7 0 % R
% Ser: 0 7 0 0 0 0 0 67 0 0 0 7 7 0 0 % S
% Thr: 7 0 7 0 0 0 0 0 7 0 7 0 7 47 0 % T
% Val: 0 0 7 0 34 0 0 0 0 7 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 7 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _