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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LIG4
All Species:
20.91
Human Site:
S390
Identified Species:
32.86
UniProt:
P49917
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49917
NP_001091738.1
911
103971
S390
R
K
R
Y
E
I
L
S
S
I
F
T
P
I
P
Chimpanzee
Pan troglodytes
XP_509726
911
103942
S390
R
K
R
Y
E
I
L
S
S
I
F
T
P
I
P
Rhesus Macaque
Macaca mulatta
XP_001084107
642
73046
L166
N
S
A
K
R
K
D
L
I
K
K
S
L
L
Q
Dog
Lupus familis
XP_542663
911
104163
T390
K
K
R
Y
E
I
L
T
S
V
F
T
P
I
P
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTF7
911
104067
S390
R
K
R
Y
E
I
L
S
S
T
F
T
P
I
Q
Rat
Rattus norvegicus
NP_001099565
911
104477
S390
R
K
R
Y
D
I
L
S
S
T
F
T
P
I
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90YB1
912
104431
S395
S
K
R
Y
K
I
L
S
N
V
F
T
P
L
T
Frog
Xenopus laevis
NP_001081114
911
104084
K395
R
K
R
Y
D
I
L
K
E
I
F
I
P
I
P
Zebra Danio
Brachydanio rerio
NP_001096593
909
103624
E395
K
K
R
Y
E
S
L
E
T
V
F
S
P
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572907
918
104813
Q399
I
Q
R
A
Y
K
L
Q
K
L
I
V
E
Q
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188102
952
108709
P427
K
E
R
L
N
Y
L
P
K
V
F
T
V
I
E
Poplar Tree
Populus trichocarpa
XP_002325262
1242
139306
R373
K
E
R
H
E
L
L
R
K
V
V
K
P
V
K
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LL84
1219
137833
K365
K
E
R
H
E
L
L
K
K
V
V
K
P
L
K
Baker's Yeast
Sacchar. cerevisiae
Q08387
944
108496
N405
H
Q
R
K
Q
Y
L
N
S
I
L
S
P
L
K
Red Bread Mold
Neurospora crassa
Q7SB49
1046
118891
E457
N
D
R
R
R
A
L
E
R
A
V
V
G
V
H
Conservation
Percent
Protein Identity:
100
99.4
68.9
91
N.A.
86.9
86.1
N.A.
N.A.
76.5
72.5
64.1
N.A.
29.7
N.A.
N.A.
48.5
Protein Similarity:
100
99.7
69.8
95.5
N.A.
92.5
92
N.A.
N.A.
87.1
84
79.3
N.A.
51.3
N.A.
N.A.
65.4
P-Site Identity:
100
100
0
80
N.A.
86.6
80
N.A.
N.A.
60
73.3
53.3
N.A.
13.3
N.A.
N.A.
33.3
P-Site Similarity:
100
100
13.3
100
N.A.
86.6
86.6
N.A.
N.A.
86.6
80
80
N.A.
26.6
N.A.
N.A.
53.3
Percent
Protein Identity:
27.2
N.A.
N.A.
27.6
25.5
29.2
Protein Similarity:
43.3
N.A.
N.A.
44.9
46.9
47.2
P-Site Identity:
26.6
N.A.
N.A.
26.6
33.3
13.3
P-Site Similarity:
66.6
N.A.
N.A.
66.6
66.6
20
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
7
7
0
7
0
0
0
7
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
0
14
0
7
0
0
0
0
0
0
0
0
% D
% Glu:
0
20
0
0
47
0
0
14
7
0
0
0
7
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
60
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% G
% His:
7
0
0
14
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
7
0
0
0
0
47
0
0
7
27
7
7
0
54
0
% I
% Lys:
34
54
0
14
7
14
0
14
27
7
7
14
0
0
27
% K
% Leu:
0
0
0
7
0
14
94
7
0
7
7
0
7
27
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
14
0
0
0
7
0
0
7
7
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
7
0
0
0
0
74
0
27
% P
% Gln:
0
14
0
0
7
0
0
7
0
0
0
0
0
7
20
% Q
% Arg:
34
0
94
7
14
0
0
7
7
0
0
0
0
0
0
% R
% Ser:
7
7
0
0
0
7
0
34
40
0
0
20
0
0
7
% S
% Thr:
0
0
0
0
0
0
0
7
7
14
0
47
0
0
7
% T
% Val:
0
0
0
0
0
0
0
0
0
40
20
14
7
14
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
54
7
14
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _