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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG4 All Species: 16.36
Human Site: S672 Identified Species: 25.71
UniProt: P49917 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49917 NP_001091738.1 911 103971 S672 C V M S G T D S Q P K P D L E
Chimpanzee Pan troglodytes XP_509726 911 103942 S672 C V M S G T D S Q P K P D L E
Rhesus Macaque Macaca mulatta XP_001084107 642 73046 T410 V Q K T Q A H T K N E V I D A
Dog Lupus familis XP_542663 911 104163 S672 C V M S G T D S H P K P D L E
Cat Felis silvestris
Mouse Mus musculus Q8BTF7 911 104067 G672 C V M S G L D G Y P K A D L E
Rat Rattus norvegicus NP_001099565 911 104477 G672 C V M S G L D G Y P K P D L E
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YB1 912 104431 R677 C V M T G M G R Y S K S E L E
Frog Xenopus laevis NP_001081114 911 104084 Q675 C V M S G T D Q H S K A D L E
Zebra Danio Brachydanio rerio NP_001096593 909 103624 E676 C V I N G D D E H S K A E L E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572907 918 104813 G684 C I L S G S A G R H S K H Q L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188102 952 108709 S710 C I M N S P A S H P K D Q L E
Poplar Tree Populus trichocarpa XP_002325262 1242 139306 S678 Y F V N V P P S N S L E S L H
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LL84 1219 137833 S669 Y F V N V P R S H S L E T F H
Baker's Yeast Sacchar. cerevisiae Q08387 944 108496 T699 Y V L S D Y V T E D T G I R I
Red Bread Mold Neurospora crassa Q7SB49 1046 118891 K756 C V L S D S L K P N K M T K P
Conservation
Percent
Protein Identity: 100 99.4 68.9 91 N.A. 86.9 86.1 N.A. N.A. 76.5 72.5 64.1 N.A. 29.7 N.A. N.A. 48.5
Protein Similarity: 100 99.7 69.8 95.5 N.A. 92.5 92 N.A. N.A. 87.1 84 79.3 N.A. 51.3 N.A. N.A. 65.4
P-Site Identity: 100 100 0 93.3 N.A. 73.3 80 N.A. N.A. 46.6 73.3 46.6 N.A. 20 N.A. N.A. 46.6
P-Site Similarity: 100 100 26.6 93.3 N.A. 73.3 80 N.A. N.A. 60 73.3 66.6 N.A. 46.6 N.A. N.A. 60
Percent
Protein Identity: 27.2 N.A. N.A. 27.6 25.5 29.2
Protein Similarity: 43.3 N.A. N.A. 44.9 46.9 47.2
P-Site Identity: 13.3 N.A. N.A. 6.6 13.3 26.6
P-Site Similarity: 26.6 N.A. N.A. 20 33.3 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 14 0 0 0 0 20 0 0 7 % A
% Cys: 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 14 7 47 0 0 7 0 7 40 7 0 % D
% Glu: 0 0 0 0 0 0 0 7 7 0 7 14 14 0 60 % E
% Phe: 0 14 0 0 0 0 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 0 0 60 0 7 20 0 0 0 7 0 0 0 % G
% His: 0 0 0 0 0 0 7 0 34 7 0 0 7 0 14 % H
% Ile: 0 14 7 0 0 0 0 0 0 0 0 0 14 0 7 % I
% Lys: 0 0 7 0 0 0 0 7 7 0 67 7 0 7 0 % K
% Leu: 0 0 20 0 0 14 7 0 0 0 14 0 0 67 7 % L
% Met: 0 0 54 0 0 7 0 0 0 0 0 7 0 0 0 % M
% Asn: 0 0 0 27 0 0 0 0 7 14 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 20 7 0 7 40 0 27 0 0 7 % P
% Gln: 0 7 0 0 7 0 0 7 14 0 0 0 7 7 0 % Q
% Arg: 0 0 0 0 0 0 7 7 7 0 0 0 0 7 0 % R
% Ser: 0 0 0 60 7 14 0 40 0 34 7 7 7 0 0 % S
% Thr: 0 0 0 14 0 27 0 14 0 0 7 0 14 0 0 % T
% Val: 7 67 14 0 14 0 7 0 0 0 0 7 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 20 0 0 0 0 7 0 0 20 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _