Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.

Updated: 2017 Aug. 1

| Home | Kinexus | Contact | Credits

Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG4 All Species: 30.61
Human Site: T542 Identified Species: 48.1
UniProt: P49917 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.21
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49917 NP_001091738.1 911 103971 T542 P S S I L C G T E K P E V Y I
Chimpanzee Pan troglodytes XP_509726 911 103942 T542 P S S I L C G T E K P E V Y I
Rhesus Macaque Macaca mulatta XP_001084107 642 73046 A304 N Y T D Q F G A S P T E G S L
Dog Lupus familis XP_542663 911 104163 T542 P S S I L C G T E K P E V Y I
Cat Felis silvestris
Mouse Mus musculus Q8BTF7 911 104067 T542 P S S I L C G T E K P E V Y I
Rat Rattus norvegicus NP_001099565 911 104477 T542 P S C I L C G T E K P E V Y I
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YB1 912 104431 T547 P C N I L C G T E K P E M Y I
Frog Xenopus laevis NP_001081114 911 104084 I547 P S N I L C G I E K P E V F I
Zebra Danio Brachydanio rerio NP_001096593 909 103624 T547 P A A I L C G T E K P E V Y I
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572907 918 104813 S553 H Y K P K E R S G C P D L W I
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188102 952 108709 R580 P R W L Q C T R E K P E L Y V
Poplar Tree Populus trichocarpa XP_002325262 1242 139306 R547 V T N N S K E R P D V W I E N
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LL84 1219 137833 R539 V T N H S K E R P D V W I D S
Baker's Yeast Sacchar. cerevisiae Q08387 944 108496 G576 P A S I L E F G S K I P A E W
Red Bread Mold Neurospora crassa Q7SB49 1046 118891 Y620 G G G E K L Q Y E K P D V W I
Conservation
Percent
Protein Identity: 100 99.4 68.9 91 N.A. 86.9 86.1 N.A. N.A. 76.5 72.5 64.1 N.A. 29.7 N.A. N.A. 48.5
Protein Similarity: 100 99.7 69.8 95.5 N.A. 92.5 92 N.A. N.A. 87.1 84 79.3 N.A. 51.3 N.A. N.A. 65.4
P-Site Identity: 100 100 13.3 100 N.A. 100 93.3 N.A. N.A. 80 80 86.6 N.A. 13.3 N.A. N.A. 46.6
P-Site Similarity: 100 100 26.6 100 N.A. 100 93.3 N.A. N.A. 93.3 93.3 100 N.A. 40 N.A. N.A. 66.6
Percent
Protein Identity: 27.2 N.A. N.A. 27.6 25.5 29.2
Protein Similarity: 43.3 N.A. N.A. 44.9 46.9 47.2
P-Site Identity: 0 N.A. N.A. 0 33.3 33.3
P-Site Similarity: 20 N.A. N.A. 20 40 46.6
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 14 7 0 0 0 0 7 0 0 0 0 7 0 0 % A
% Cys: 0 7 7 0 0 60 0 0 0 7 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 0 0 0 14 0 14 0 7 0 % D
% Glu: 0 0 0 7 0 14 14 0 67 0 0 67 0 14 0 % E
% Phe: 0 0 0 0 0 7 7 0 0 0 0 0 0 7 0 % F
% Gly: 7 7 7 0 0 0 60 7 7 0 0 0 7 0 0 % G
% His: 7 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 60 0 0 0 7 0 0 7 0 14 0 67 % I
% Lys: 0 0 7 0 14 14 0 0 0 74 0 0 0 0 0 % K
% Leu: 0 0 0 7 60 7 0 0 0 0 0 0 14 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % M
% Asn: 7 0 27 7 0 0 0 0 0 0 0 0 0 0 7 % N
% Pro: 67 0 0 7 0 0 0 0 14 7 74 7 0 0 0 % P
% Gln: 0 0 0 0 14 0 7 0 0 0 0 0 0 0 0 % Q
% Arg: 0 7 0 0 0 0 7 20 0 0 0 0 0 0 0 % R
% Ser: 0 40 34 0 14 0 0 7 14 0 0 0 0 7 7 % S
% Thr: 0 14 7 0 0 0 7 47 0 0 7 0 0 0 0 % T
% Val: 14 0 0 0 0 0 0 0 0 0 14 0 54 0 7 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 0 14 0 14 7 % W
% Tyr: 0 14 0 0 0 0 0 7 0 0 0 0 0 54 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _