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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
LIG4
All Species:
27.88
Human Site:
Y112
Identified Species:
43.81
UniProt:
P49917
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49917
NP_001091738.1
911
103971
Y112
D
A
L
K
L
L
N
Y
R
T
P
T
G
T
H
Chimpanzee
Pan troglodytes
XP_509726
911
103942
Y112
D
A
L
K
L
L
N
Y
R
T
P
T
G
T
H
Rhesus Macaque
Macaca mulatta
XP_001084107
642
73046
Dog
Lupus familis
XP_542663
911
104163
Y112
D
A
L
K
L
L
N
Y
R
T
P
T
G
T
R
Cat
Felis silvestris
Mouse
Mus musculus
Q8BTF7
911
104067
Y112
D
A
Q
K
L
L
N
Y
R
T
P
S
G
A
R
Rat
Rattus norvegicus
NP_001099565
911
104477
Y112
D
A
Q
K
L
L
N
Y
R
T
P
S
G
A
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Q90YB1
912
104431
Y117
D
A
V
K
L
L
N
Y
R
T
P
T
G
S
R
Frog
Xenopus laevis
NP_001081114
911
104084
Y117
D
A
L
K
L
L
N
Y
R
T
P
T
S
S
H
Zebra Danio
Brachydanio rerio
NP_001096593
909
103624
Y117
E
A
N
K
L
L
N
Y
R
A
P
T
T
S
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572907
918
104813
R110
T
D
S
S
D
A
I
R
L
Q
H
R
N
G
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001188102
952
108709
N149
T
D
A
K
K
L
L
N
Y
R
A
P
T
A
K
Poplar Tree
Populus trichocarpa
XP_002325262
1242
139306
A104
I
N
W
R
K
G
G
A
N
A
T
G
A
N
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LL84
1219
137833
G104
A
K
A
G
A
N
A
G
N
F
S
L
I
A
A
Baker's Yeast
Sacchar. cerevisiae
Q08387
944
108496
L112
N
S
A
T
E
Q
R
L
K
D
W
K
Q
R
V
Red Bread Mold
Neurospora crassa
Q7SB49
1046
118891
G160
M
H
W
K
L
P
G
G
Q
S
G
V
S
R
S
Conservation
Percent
Protein Identity:
100
99.4
68.9
91
N.A.
86.9
86.1
N.A.
N.A.
76.5
72.5
64.1
N.A.
29.7
N.A.
N.A.
48.5
Protein Similarity:
100
99.7
69.8
95.5
N.A.
92.5
92
N.A.
N.A.
87.1
84
79.3
N.A.
51.3
N.A.
N.A.
65.4
P-Site Identity:
100
100
0
93.3
N.A.
73.3
73.3
N.A.
N.A.
80
86.6
60
N.A.
0
N.A.
N.A.
13.3
P-Site Similarity:
100
100
0
93.3
N.A.
80
80
N.A.
N.A.
93.3
93.3
73.3
N.A.
6.6
N.A.
N.A.
13.3
Percent
Protein Identity:
27.2
N.A.
N.A.
27.6
25.5
29.2
Protein Similarity:
43.3
N.A.
N.A.
44.9
46.9
47.2
P-Site Identity:
0
N.A.
N.A.
0
0
13.3
P-Site Similarity:
6.6
N.A.
N.A.
0
20
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
54
20
0
7
7
7
7
0
14
7
0
7
27
14
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
47
14
0
0
7
0
0
0
0
7
0
0
0
0
0
% D
% Glu:
7
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
0
0
7
0
7
14
14
0
0
7
7
40
7
0
% G
% His:
0
7
0
0
0
0
0
0
0
0
7
0
0
0
20
% H
% Ile:
7
0
0
0
0
0
7
0
0
0
0
0
7
0
0
% I
% Lys:
0
7
0
67
14
0
0
0
7
0
0
7
0
0
7
% K
% Leu:
0
0
27
0
60
60
7
7
7
0
0
7
0
0
0
% L
% Met:
7
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
7
7
0
0
7
54
7
14
0
0
0
7
7
7
% N
% Pro:
0
0
0
0
0
7
0
0
0
0
54
7
0
0
0
% P
% Gln:
0
0
14
0
0
7
0
0
7
7
0
0
7
0
7
% Q
% Arg:
0
0
0
7
0
0
7
7
54
7
0
7
0
14
27
% R
% Ser:
0
7
7
7
0
0
0
0
0
7
7
14
14
20
7
% S
% Thr:
14
0
0
7
0
0
0
0
0
47
7
40
14
20
0
% T
% Val:
0
0
7
0
0
0
0
0
0
0
0
7
0
0
7
% V
% Trp:
0
0
14
0
0
0
0
0
0
0
7
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
54
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _