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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: LIG4 All Species: 10.3
Human Site: Y801 Identified Species: 16.19
UniProt: P49917 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P49917 NP_001091738.1 911 103971 Y801 S L I A D L E Y R Y S W D C S
Chimpanzee Pan troglodytes XP_509726 911 103942 Y801 S L I A D L E Y R Y S W D C S
Rhesus Macaque Macaca mulatta XP_001084107 642 73046 S536 F H K K A P P S S I L C G T E
Dog Lupus familis XP_542663 911 104163 Y801 S L I A D L E Y R Y S W D R S
Cat Felis silvestris
Mouse Mus musculus Q8BTF7 911 104067 C801 P V I A D L E C R Y S W D H S
Rat Rattus norvegicus NP_001099565 911 104477 C801 P V I A D L E C R Y S W D H S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q90YB1 912 104431 W806 E L E E R Y S W N S C K L C I
Frog Xenopus laevis NP_001081114 911 104084 S804 A N L E E R Y S W N N S S Y N
Zebra Danio Brachydanio rerio NP_001096593 909 103624 A803 A Q I E A E N A W D D L P T S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_572907 918 104813 N812 V A G I T A S N L N A L E D Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001188102 952 108709 D839 Q I A E I E M D Y F P Q D S L
Poplar Tree Populus trichocarpa XP_002325262 1242 139306 E806 K Q K Y C P E E K W S L F H G
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q9LL84 1219 137833 K797 K K K L C P E K R W S C L L S
Baker's Yeast Sacchar. cerevisiae Q08387 944 108496 L838 S E V R R F P L F L F S N R I
Red Bread Mold Neurospora crassa Q7SB49 1046 118891 G887 E L K A I M E G M E S D D Y V
Conservation
Percent
Protein Identity: 100 99.4 68.9 91 N.A. 86.9 86.1 N.A. N.A. 76.5 72.5 64.1 N.A. 29.7 N.A. N.A. 48.5
Protein Similarity: 100 99.7 69.8 95.5 N.A. 92.5 92 N.A. N.A. 87.1 84 79.3 N.A. 51.3 N.A. N.A. 65.4
P-Site Identity: 100 100 0 93.3 N.A. 73.3 73.3 N.A. N.A. 13.3 0 13.3 N.A. 0 N.A. N.A. 6.6
P-Site Similarity: 100 100 0 93.3 N.A. 80 80 N.A. N.A. 20 33.3 20 N.A. 13.3 N.A. N.A. 20
Percent
Protein Identity: 27.2 N.A. N.A. 27.6 25.5 29.2
Protein Similarity: 43.3 N.A. N.A. 44.9 46.9 47.2
P-Site Identity: 13.3 N.A. N.A. 26.6 6.6 33.3
P-Site Similarity: 26.6 N.A. N.A. 33.3 20 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 14 7 7 40 14 7 0 7 0 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 14 0 0 14 0 0 7 14 0 20 0 % C
% Asp: 0 0 0 0 34 0 0 7 0 7 7 7 47 7 0 % D
% Glu: 14 7 7 27 7 14 54 7 0 7 0 0 7 0 7 % E
% Phe: 7 0 0 0 0 7 0 0 7 7 7 0 7 0 0 % F
% Gly: 0 0 7 0 0 0 0 7 0 0 0 0 7 0 7 % G
% His: 0 7 0 0 0 0 0 0 0 0 0 0 0 20 0 % H
% Ile: 0 7 40 7 14 0 0 0 0 7 0 0 0 0 14 % I
% Lys: 14 7 27 7 0 0 0 7 7 0 0 7 0 0 0 % K
% Leu: 0 34 7 7 0 34 0 7 7 7 7 20 14 7 7 % L
% Met: 0 0 0 0 0 7 7 0 7 0 0 0 0 0 0 % M
% Asn: 0 7 0 0 0 0 7 7 7 14 7 0 7 0 7 % N
% Pro: 14 0 0 0 0 20 14 0 0 0 7 0 7 0 0 % P
% Gln: 7 14 0 0 0 0 0 0 0 0 0 7 0 0 7 % Q
% Arg: 0 0 0 7 14 7 0 0 40 0 0 0 0 14 0 % R
% Ser: 27 0 0 0 0 0 14 14 7 7 54 14 7 7 47 % S
% Thr: 0 0 0 0 7 0 0 0 0 0 0 0 0 14 0 % T
% Val: 7 14 7 0 0 0 0 0 0 0 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 7 14 14 0 34 0 0 0 % W
% Tyr: 0 0 0 7 0 7 7 20 7 34 0 0 0 14 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _