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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MRE11A
All Species:
27.27
Human Site:
S183
Identified Species:
42.86
UniProt:
P49959
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P49959
NP_005581.2
708
80593
S183
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Chimpanzee
Pan troglodytes
XP_001142343
708
80653
S183
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_542244
708
80700
S183
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q61216
706
80204
S183
L
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Rat
Rattus norvegicus
Q9JIM0
706
80103
S183
L
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513434
706
80323
S183
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Chicken
Gallus gallus
Q9IAM7
700
80005
A183
I
A
L
Y
G
L
G
A
I
P
D
E
R
L
Y
Frog
Xenopus laevis
Q9W6K1
711
81112
S184
I
A
L
Y
G
L
G
S
I
P
D
E
R
L
Y
Zebra Danio
Brachydanio rerio
NP_001001407
619
70401
L170
V
E
I
S
P
V
L
L
Q
K
G
D
T
R
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_523547
620
69267
M171
V
E
I
S
P
V
L
M
R
K
G
E
S
Q
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23255
728
81540
Q236
A
L
Y
G
I
G
S
Q
R
D
D
R
L
V
R
Sea Urchin
Strong. purpuratus
XP_798167
515
58684
H69
K
P
S
R
K
S
L
H
G
V
M
T
L
L
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9XGM2
720
80272
G180
S
T
T
V
A
L
Y
G
L
G
N
I
R
D
E
Baker's Yeast
Sacchar. cerevisiae
P32829
692
77632
A179
L
A
L
Y
G
L
A
A
V
R
D
E
R
L
F
Red Bread Mold
Neurospora crassa
Q9C291
739
83526
N178
M
A
L
Y
G
L
S
N
V
R
D
E
R
M
H
Conservation
Percent
Protein Identity:
100
99.4
N.A.
93.7
N.A.
88.2
88.4
N.A.
85
73.5
72.8
61.2
N.A.
39.5
N.A.
32.6
42.6
Protein Similarity:
100
99.4
N.A.
97.1
N.A.
93.7
93.7
N.A.
92.3
85.5
85
75.2
N.A.
55.6
N.A.
50.6
56.9
P-Site Identity:
100
100
N.A.
100
N.A.
93.3
93.3
N.A.
100
93.3
100
0
N.A.
6.6
N.A.
6.6
6.6
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
100
26.6
N.A.
26.6
N.A.
13.3
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
38.1
35.3
33.8
Protein Similarity:
N.A.
N.A.
N.A.
57.9
53.3
52.5
P-Site Identity:
N.A.
N.A.
N.A.
13.3
60
53.3
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
86.6
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
67
0
0
7
0
7
14
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
7
74
7
0
7
0
% D
% Glu:
0
14
0
0
0
0
0
0
0
0
0
74
0
0
7
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% F
% Gly:
0
0
0
7
67
7
54
7
7
7
14
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
7
0
0
0
0
0
0
7
% H
% Ile:
40
0
14
0
7
0
0
0
54
0
0
7
0
0
7
% I
% Lys:
7
0
0
0
7
0
0
0
0
14
0
0
0
0
0
% K
% Leu:
20
7
67
0
0
74
20
7
7
0
0
0
14
67
7
% L
% Met:
7
0
0
0
0
0
0
7
0
0
7
0
0
7
0
% M
% Asn:
0
0
0
0
0
0
0
7
0
0
7
0
0
0
0
% N
% Pro:
0
7
0
0
14
0
0
0
0
54
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
7
7
0
0
0
0
7
0
% Q
% Arg:
0
0
0
7
0
0
0
0
14
14
0
7
74
7
14
% R
% Ser:
7
0
7
14
0
7
14
47
0
0
0
0
7
0
0
% S
% Thr:
0
7
7
0
0
0
0
0
0
0
0
7
7
0
0
% T
% Val:
14
0
0
7
0
14
0
0
14
7
0
0
0
7
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
67
0
0
7
0
0
0
0
0
0
0
54
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _